| Player | Team | Action | Details | |
|---|---|---|---|---|
| A.J. Minter | Chinballs | ADD | to MLB | 10:47 am, 8/14/22 |
| Justin Dirden | Monk's Café | ADD | to AAA | 8:32 am, 8/14/22 |
| Bryce Elder | Monk's Café | ADD | to MLB | 1:37 am, 8/14/22 |
| Christian Vazquez | Undead Rabbits | ADD | to MLB | 10:23 am, 8/13/22 |
| Mike Yastrzemski | Undead Rabbits | ADD | to MLB | 10:23 am, 8/13/22 |
| Riley Adams | The Red Barons | ADD | to MLB | 12:38 am, 8/13/22 |
| Ryan Noda | Ye Olde Tom Toolshed | ADD | to AAA | 12:33 am, 8/13/22 |
| Joey Meneses | The Red Barons | ADD | to MLB | 12:32 am, 8/13/22 |
| Yainer Diaz | Chinballs | ADD | to NA | 8:58 pm, 8/12/22 |
| Yadier Molina | Undead Rabbits | ADD | to MLB | 8:02 pm, 8/12/22 |
| Adam Frazier | Undead Rabbits | ADD | to MLB | 2:55 pm, 8/12/22 |
| Christian Arroyo | Undead Rabbits | ADD | to MLB | 2:54 pm, 8/12/22 |
| Tommy Pham | Undead Rabbits | ADD | to MLB | 2:54 pm, 8/12/22 |
| J.D. Davis | The Red Barons | ADD | to MLB | 9:41 am, 8/12/22 |
| Nick Nastrini | Geckos | ADD | to AA | 1:06 pm, 8/11/22 |
| Sam Haggerty | Ye Olde Tom Toolshed | ADD | to MLB | 6:09 am, 8/11/22 |
| Andre Pallante | Ye Olde Tom Toolshed | ADD | to AAA | 3:26 pm, 8/10/22 |
| Mark Melancon | Ye Olde Tom Toolshed | ADD | to MLB | 9:28 am, 8/10/22 |
| Jaison Chourio | Monk's Café | ADD | to A | 7:12 am, 8/10/22 |
| Domingo German | Monk's Café | ADD | to MLB | 6:35 am, 8/10/22 |
| Frank Schwindel | The Red Barons | ADD | to AAA | 9:59 pm, 8/9/22 |
| Jeurys Familia | Undead Rabbits | ADD | to AAA | 7:11 pm, 8/9/22 |
| Hao Yu Lee | The Red Barons | ADD | to A | 7:01 pm, 8/9/22 |
| Nelson Velasquez | Chinballs | ADD | to AAA | 1:57 pm, 8/9/22 |
| Samuel Zavala | Chinballs | ADD | to A | 1:57 pm, 8/9/22 |