| Player | Team | Action | Details | |
|---|---|---|---|---|
| Cesar Prieto | The Bluth Company | ADD | to AAA | 1:04 pm, 4/25/22 |
| Griff McGarry | The Bluth Company | ADD | to AA | 1:01 pm, 4/25/22 |
| Brandon Walter | The Bluth Company | ADD | to AA | 12:59 pm, 4/25/22 |
| Jake Junis | Ye Olde Tom Toolshed | ADD | to MLB | 11:24 am, 4/25/22 |
| Ji-Man Choi | Supreme Clientele | ADD | to MLB | 11:02 am, 4/25/22 |
| Johan Camargo | Supreme Clientele | ADD | to MLB | 11:02 am, 4/25/22 |
| Kyle Freeland | Supreme Clientele | ADD | to MLB | 11:01 am, 4/25/22 |
| Yandy Diaz | Supreme Clientele | ADD | to MLB | 11:01 am, 4/25/22 |
| Deyvison De Los Santos | Bullet Club | ADD | to MLB | 10:04 am, 4/25/22 |
| Joey Wendle | Chinballs | ADD | to MLB | 4:46 am, 4/25/22 |
| Christian Encarnacion-Strand | Chinballs | ADD | to AA | 9:32 pm, 4/24/22 |
| Jose Suarez | Undead Rabbits | ADD | to MLB | 12:51 pm, 4/24/22 |
| Rich Hill | Undead Rabbits | ADD | to MLB | 12:51 pm, 4/24/22 |
| Alex Binelas | The Bluth Company | ADD | to AA | 11:56 am, 4/24/22 |
| Humberto Castellanos | Bullet Club | ADD | to MLB | 9:44 pm, 4/23/22 |
| Matt Barnes | Cowboys From Hell | ADD | to MLB | 10:24 am, 4/23/22 |
| Adam Oller | Supreme Clientele | ADD | to MLB | 8:12 pm, 4/22/22 |
| Zack Collins | Supreme Clientele | ADD | to MLB | 8:12 pm, 4/22/22 |
| Albert Pujols | Supreme Clientele | ADD | to MLB | 8:12 pm, 4/22/22 |
| Ty Madden | Chinballs | ADD | to AAA | 7:58 pm, 4/22/22 |
| Adrian Chaidez | The Bluth Company | ADD | to AA | 1:33 pm, 4/22/22 |
| Steven Wilson | The Bluth Company | ADD | to MLB | 1:32 pm, 4/22/22 |
| Tony Kemp | Kimble's Kids | ADD | to MLB | 1:24 pm, 4/22/22 |
| Jordyn Adams | Bullet Club | ADD | to AA | 9:56 am, 4/22/22 |
| Sam Long | Bullet Club | ADD | to MLB | 8:32 am, 4/22/22 |