| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jose Ramos | The Bluth Company | ADD | to A | 10:24 pm, 4/5/22 |
| Freddy Tarnok | The Bluth Company | ADD | to AA | 10:24 pm, 4/5/22 |
| Jose Tena | Geckos | ADD | to A | 10:22 pm, 4/5/22 |
| Jordan Wicks | Geckos | ADD | to AA | 10:21 pm, 4/5/22 |
| Joshua Mears | Geckos | ADD | to A | 10:19 pm, 4/5/22 |
| Omar Narvaez | Supreme Clientele | ADD | to MLB | 4:34 pm, 4/5/22 |
| Aaron Zavala | Ye Olde Tom Toolshed | ADD | to A | 12:15 pm, 4/5/22 |
| Connor Norby | Ye Olde Tom Toolshed | ADD | to A | 12:15 pm, 4/5/22 |
| Colson Montgomery | Ye Olde Tom Toolshed | ADD | to A | 12:14 pm, 4/5/22 |
| Diego Castillo | Cowboys From Hell | ADD | to MLB | 12:12 pm, 4/5/22 |
| Andrew McCutchen | The Red Barons | ADD | to MLB | 12:04 pm, 4/5/22 |
| Carter Kieboom | The Red Barons | ADD | to MLB | 12:03 pm, 4/5/22 |
| Andres Munoz | Undead Rabbits | ADD | to AA | 10:39 am, 4/5/22 |
| Ryne Nelson | The Bluth Company | ADD | to MLB | 12:49 am, 4/5/22 |
| Michael Fulmer | Monk's Café | ADD | to MLB | 11:20 pm, 4/4/22 |
| Chris Rodriguez | Monk's Café | ADD | to AAA | 11:19 pm, 4/4/22 |
| Kevin Smith | Ye Olde Tom Toolshed | ADD | to MLB | 11:18 pm, 4/4/22 |
| Domingo German | The Bluth Company | ADD | to MLB | 11:16 pm, 4/4/22 |
| Yadier Molina | Jon Voight's Car | ADD | to MLB | 11:16 pm, 4/4/22 |
| Seth Johnson | Nixon's Nasty Ninjas | ADD | to AAA | 11:16 pm, 4/4/22 |
| Nicky Lopez | Bullet Club | ADD | to MLB | 11:11 pm, 4/4/22 |
| Adrian Houser | Bullet Club | ADD | to MLB | 11:10 pm, 4/4/22 |
| Jorge Mateo | Monk's Café | ADD | to MLB | 11:09 pm, 4/4/22 |
| Nick Solak | Undead Rabbits | ADD | to MLB | 11:09 pm, 4/4/22 |
| Zach Thompson | Chinballs | ADD | to MLB | 11:09 pm, 4/4/22 |