| Player | Team | Action | Details | |
|---|---|---|---|---|
| Enrique Hernandez | Scranton Yankees | ADD | to MLB | 12:37 pm, 7/8/21 |
| Michael Wacha | Scranton Yankees | ADD | to MLB | 12:35 pm, 7/8/21 |
| Adam Ottavino | Scranton Yankees | ADD | to MLB | 12:34 pm, 7/8/21 |
| Chad Green | Scranton Yankees | ADD | to MLB | 12:34 pm, 7/8/21 |
| Orlando Arcia | Scranton Yankees | ADD | to MLB | 12:34 pm, 7/8/21 |
| J.A. Happ | Bullet Club | ADD | to MLB | 11:10 am, 7/8/21 |
| Paolo Espino | Ye Olde Tom Toolshed | ADD | to MLB | 11:13 am, 7/7/21 |
| Chad Kuhl | The Red Barons | ADD | to MLB | 7:23 am, 7/7/21 |
| Harold Ramirez | Purple Cobras | ADD | to MLB | 5:23 am, 7/7/21 |
| Wily Peralta | Undead Rabbits | ADD | to MLB | 11:46 pm, 7/6/21 |
| Garrett Richards | Undead Rabbits | ADD | to MLB | 11:46 pm, 7/6/21 |
| Leury Garcia | Undead Rabbits | ADD | to MLB | 11:45 pm, 7/6/21 |
| Rowdy Tellez | Undead Rabbits | ADD | to AAA | 11:42 pm, 7/6/21 |
| Jake Bauers | Bullet Club | ADD | to MLB | 10:08 pm, 7/6/21 |
| Starlin Castro | Bullet Club | ADD | to MLB | 10:07 pm, 7/6/21 |
| Calvin Mitchell | The Bluth Company | ADD | to A | 9:54 pm, 7/6/21 |
| Paul Sewald | Bullet Club | ADD | to MLB | 7:19 pm, 7/6/21 |
| Jose Rojas | Shaolin Schmeckles | ADD | to MLB | 6:45 pm, 7/6/21 |
| Ben Gamel | Ye Olde Tom Toolshed | ADD | to MLB | 10:19 am, 7/6/21 |
| Alec Mills | Ye Olde Tom Toolshed | ADD | to MLB | 10:19 am, 7/6/21 |
| Drew Steckenrider | Ye Olde Tom Toolshed | ADD | to MLB | 10:19 am, 7/6/21 |
| Jahmai Jones | Purple Cobras | ADD | to AA | 6:53 am, 7/6/21 |
| Eric Haase | Supreme Clientele | ADD | to MLB | 3:53 pm, 7/5/21 |
| Scott Barlow | Supreme Clientele | ADD | to MLB | 3:37 pm, 7/5/21 |
| Ranger Suarez | Supreme Clientele | ADD | to MLB | 3:37 pm, 7/5/21 |