| Player | Team | Action | Details | |
|---|---|---|---|---|
| Braden Shewmake | Supreme Clientele | ADD | to NA | 9:14 pm, 4/23/21 |
| Martin Perez | Undead Rabbits | ADD | to MLB | 5:34 pm, 4/23/21 |
| J.A. Happ | Supreme Clientele | ADD | to MLB | 1:26 pm, 4/23/21 |
| Kyle Freeland | Supreme Clientele | ADD | to MLB | 1:26 pm, 4/23/21 |
| Patrick Bailey | The Bluth Company | ADD | to A | 11:51 pm, 4/22/21 |
| Kyle Harrison | Bullet Club | ADD | to AA | 10:35 am, 4/22/21 |
| Wilmer Flores | Geckos | ADD | to MLB | 10:17 am, 4/22/21 |
| Seth Brown | The Bluth Company | ADD | to AAA | 8:26 pm, 4/21/21 |
| Pavin Smith | The Bluth Company | ADD | to AAA | 7:12 pm, 4/21/21 |
| Adam Frazier | Geckos | ADD | to MLB | 3:01 pm, 4/21/21 |
| Miguel Rojas | Purple Cobras | ADD | to MLB | 2:19 pm, 4/21/21 |
| Jordan Luplow | Purple Cobras | ADD | to MLB | 2:19 pm, 4/21/21 |
| Drew Rasmussen | Ye Olde Tom Toolshed | ADD | to MLB | 11:29 am, 4/21/21 |
| Ross Stripling | Ye Olde Tom Toolshed | ADD | to MLB | 11:29 am, 4/21/21 |
| Jordan Lyles | The Bluth Company | ADD | to MLB | 10:32 pm, 4/20/21 |
| Aledmys Diaz | Geckos | ADD | to MLB | 1:08 pm, 4/20/21 |
| Yandy Diaz | Geckos | ADD | to MLB | 1:07 pm, 4/20/21 |
| Nick Yorke | Geckos | ADD | to A | 1:02 pm, 4/20/21 |
| Adolis Garcia | Purple Cobras | ADD | to AAA | 12:30 pm, 4/20/21 |
| Harrison Bader | The Red Barons | ADD | to MLB | 9:35 am, 4/20/21 |
| Justin Williams | The Bluth Company | ADD | to AAA | 8:53 pm, 4/19/21 |
| Zack Burdi | The Bluth Company | ADD | to AAA | 12:36 pm, 4/19/21 |
| Patrick Bailey | The Bluth Company | ADD | to AAA | 12:28 pm, 4/19/21 |
| Tyler Matzek | Geckos | ADD | to MLB | 11:42 pm, 4/18/21 |
| J.B. Bukauskas | Purple Cobras | ADD | to AAA | 11:32 am, 4/18/21 |