| Player | Team | Action | Details | |
|---|---|---|---|---|
| Abraham Toro | Geckos | ADD | to AAA | 4:30 pm, 4/14/21 |
| Lucas Sims | Purple Cobras | ADD | to MLB | 3:28 pm, 4/14/21 |
| Rowdy Tellez | Purple Cobras | ADD | to MLB | 3:28 pm, 4/14/21 |
| Alex Wood | The Red Barons | ADD | to MLB | 1:08 pm, 4/14/21 |
| Rafael Dolis | Cowboys From Hell | ADD | to MLB | 12:44 pm, 4/14/21 |
| Patrick Bailey | The Bluth Company | ADD | to AAA | 1:49 am, 4/14/21 |
| Brett Phillips | Cowboys From Hell | ADD | to MLB | 5:36 pm, 4/13/21 |
| Chris Owings | Cowboys From Hell | ADD | to MLB | 4:01 pm, 4/13/21 |
| Yan Gomes | Cowboys From Hell | ADD | to MLB | 4:01 pm, 4/13/21 |
| Wilson Ramos | Cowboys From Hell | ADD | to MLB | 4:01 pm, 4/13/21 |
| Trevor Cahill | Kimble's Kids | ADD | to MLB | 1:22 pm, 4/13/21 |
| Martin Perez | Kimble's Kids | ADD | to MLB | 1:21 pm, 4/13/21 |
| Matt Harvey | Kimble's Kids | ADD | to MLB | 1:21 pm, 4/13/21 |
| Taylor Hearn | Kimble's Kids | ADD | to MLB | 1:21 pm, 4/13/21 |
| Michael Fulmer | Chinballs | ADD | to MLB | 12:48 pm, 4/13/21 |
| Lou Trivino | Chinballs | ADD | to MLB | 12:48 pm, 4/13/21 |
| Jake Diekman | Cowboys From Hell | ADD | to MLB | 8:25 am, 4/13/21 |
| Wilmer Flores | Geckos | ADD | to MLB | 4:45 pm, 4/12/21 |
| Dan Vogelbach | Geckos | ADD | to MLB | 4:45 pm, 4/12/21 |
| Brandon Williamson | Geckos | ADD | to NA | 4:44 pm, 4/12/21 |
| Victor Caratini | Bullet Club | ADD | to MLB | 3:48 pm, 4/12/21 |
| Tyler Naquin | Supreme Clientele | ADD | to MLB | 10:31 pm, 4/11/21 |
| Johan Oviedo | The Bluth Company | ADD | to AA | 4:18 pm, 4/11/21 |
| Kevin Ginkel | Shaolin Schmeckles | ADD | to MLB | 1:04 pm, 4/11/21 |
| Jon Lester | Shaolin Schmeckles | ADD | to MLB | 1:02 pm, 4/11/21 |