| Player | Team | Action | Details | |
|---|---|---|---|---|
| Ryan Pepiot | Chinballs | ADD | to AAA | 12:52 am, 3/16/21 |
| Jonatan Clase | Chinballs | ADD | to A | 12:51 am, 3/16/21 |
| Luis Oviedo | Chinballs | ADD | to A | 12:43 am, 3/16/21 |
| Michael Grove | Chinballs | ADD | to AA | 12:41 am, 3/16/21 |
| Hunter Harvey | Chinballs | ADD | to AAA | 12:38 am, 3/16/21 |
| James Kaprielian | Chinballs | ADD | to AAA | 12:35 am, 3/16/21 |
| Brennan Malone | Chinballs | ADD | to A | 12:32 am, 3/16/21 |
| Adam Ottavino | Undead Rabbits | ADD | to MLB | 12:06 am, 3/16/21 |
| Gregory Polanco | Shaolin Schmeckles | ADD | to MLB | 12:06 am, 3/16/21 |
| Chad Kuhl | Cowboys From Hell | ADD | to MLB | 12:05 am, 3/16/21 |
| Wilmer Flores | Shaolin Schmeckles | ADD | to MLB | 12:04 am, 3/16/21 |
| Yoendrys Gomez | The Bluth Company | ADD | to AA | 12:03 am, 3/16/21 |
| Tyler Duffey | Nixon's Nasty Ninjas | ADD | to MLB | 12:03 am, 3/16/21 |
| Austin Gomber | The Red Barons | ADD | to MLB | 12:01 am, 3/16/21 |
| Matt Moore | Supreme Clientele | ADD | to MLB | 12:00 am, 3/16/21 |
| Chris Flexen | Supreme Clientele | ADD | to MLB | 12:00 am, 3/16/21 |
| Jackie Bradley Jr | Kimble's Kids | ADD | to MLB | 12:00 am, 3/16/21 |
| Odubel Herrera | Bullet Club | ADD | to MLB | 11:57 pm, 3/15/21 |
| Gilberto Celestino | Shaolin Schmeckles | ADD | to AA | 11:54 pm, 3/15/21 |
| Myles Straw | Purple Cobras | ADD | to MLB | 11:53 pm, 3/15/21 |
| Bobby Bradley | Supreme Clientele | ADD | to MLB | 11:51 pm, 3/15/21 |
| Hunter Brown | The Red Barons | ADD | to AAA | 11:51 pm, 3/15/21 |
| Jurickson Profar | Supreme Clientele | ADD | to MLB | 11:50 pm, 3/15/21 |
| Enrique Hernandez | Undead Rabbits | ADD | to MLB | 11:50 pm, 3/15/21 |
| Michael Wacha | Supreme Clientele | ADD | to MLB | 11:50 pm, 3/15/21 |