| Player | Team | Action | Details | |
|---|---|---|---|---|
| Steven Duggar | Chinballs | ADD | to MLB | 10:48 am, 6/1/21 |
| Ivan Herrera | Purple Cobras | ADD | to A | 9:36 am, 6/1/21 |
| Patrick Wisdom | Purple Cobras | ADD | to AAA | 8:39 am, 6/1/21 |
| Ervin Santana | Scranton Yankees | ADD | to MLB | 9:22 pm, 5/31/21 |
| John Gant | Scranton Yankees | ADD | to MLB | 9:21 pm, 5/31/21 |
| Michael Fulmer | Scranton Yankees | ADD | to MLB | 9:20 pm, 5/31/21 |
| Chase De Jong | Scranton Yankees | ADD | to MLB | 9:20 pm, 5/31/21 |
| Jed Lowrie | Scranton Yankees | ADD | to MLB | 9:19 pm, 5/31/21 |
| Cal Raleigh | The Bluth Company | ADD | to AAA | 9:11 pm, 5/31/21 |
| Eric Lauer | Supreme Clientele | ADD | to MLB | 12:42 pm, 5/31/21 |
| Ronnie Dawson | The Bluth Company | ADD | to AAA | 12:37 pm, 5/31/21 |
| M.J. Melendez | The Bluth Company | ADD | to AA | 12:13 pm, 5/31/21 |
| Freddy Galvis | Cowboys From Hell | ADD | to MLB | 9:42 am, 5/31/21 |
| Tucker Barnhart | Cowboys From Hell | ADD | to MLB | 9:42 am, 5/31/21 |
| Caleb Smith | Purple Cobras | ADD | to MLB | 8:30 am, 5/31/21 |
| Lyon Richardson | The Bluth Company | ADD | to A | 12:01 am, 5/30/21 |
| Hudson Haskin | Jon Voight's Car | ADD | to AAA | 7:18 pm, 5/29/21 |
| Alec Burleson | The Bluth Company | ADD | to AAA | 7:17 pm, 5/29/21 |
| Kolten Wong | Supreme Clientele | ADD | to MLB | 2:37 pm, 5/29/21 |
| Jordan Lyles | Supreme Clientele | ADD | to MLB | 2:36 pm, 5/29/21 |
| Evan Longoria | Supreme Clientele | ADD | to MLB | 2:36 pm, 5/29/21 |
| Lucas Sims | Shaolin Schmeckles | ADD | to MLB | 11:50 am, 5/29/21 |
| Niko Goodrum | Shaolin Schmeckles | ADD | to MLB | 11:50 am, 5/29/21 |
| David Fletcher | Geckos | ADD | to MLB | 11:02 am, 5/29/21 |
| Billy McKinney | Geckos | ADD | to MLB | 11:02 am, 5/29/21 |