| Player | Team | Action | Details | |
|---|---|---|---|---|
| Joe Gray Jr. | Scranton Yankees | DROP | to FA | 9:52 pm, 4/26/22 |
| Nick Solak | Geckos | DROP | to FA | 5:28 pm, 4/26/22 |
| Miguel Cabrera | Geckos | DROP | to FA | 2:10 pm, 4/26/22 |
| Collin McHugh | The Bluth Company | DROP | to FA | 1:02 pm, 4/26/22 |
| Jay Groome | The Red Barons | DROP | to FA | 11:48 am, 4/26/22 |
| Rece Hinds | Bullet Club | DROP | to FA | 11:26 am, 4/26/22 |
| David Price | Shaolin Schmeckles | DROP | to FA | 11:10 am, 4/26/22 |
| Cole Sulser | Shaolin Schmeckles | DROP | to FA | 11:07 am, 4/26/22 |
| Kyle Finnegan | Shaolin Schmeckles | DROP | to FA | 11:07 am, 4/26/22 |
| Michael King | Kimble's Kids | DROP | to FA | 10:49 am, 4/26/22 |
| Tony Kemp | Kimble's Kids | DROP | to FA | 10:47 am, 4/26/22 |
| Alex Binelas | Chinballs | DROP | to FA | 10:16 am, 4/26/22 |
| Christian Encarnacion-Strand | Chinballs | DROP | to FA | 3:57 am, 4/26/22 |
| Michael Chavis | Geckos | DROP | to FA | 1:06 pm, 4/25/22 |
| Marco Raya | The Bluth Company | DROP | to FA | 1:02 pm, 4/25/22 |
| Art Warren | The Bluth Company | DROP | to FA | 1:01 pm, 4/25/22 |
| Alex Binelas | The Bluth Company | DROP | to FA | 12:59 pm, 4/25/22 |
| Dominic Smith | Shaolin Schmeckles | DROP | to FA | 12:26 pm, 4/25/22 |
| Miguel Sano | Supreme Clientele | DROP | to FA | 11:02 am, 4/25/22 |
| Adam Oller | Supreme Clientele | DROP | to FA | 11:02 am, 4/25/22 |
| Albert Pujols | Supreme Clientele | DROP | to FA | 11:01 am, 4/25/22 |
| Max Stassi | Supreme Clientele | DROP | to FA | 11:01 am, 4/25/22 |
| Joshua Baez | Bullet Club | DROP | to FA | 10:04 am, 4/25/22 |
| Taylor Walls | Chinballs | DROP | to FA | 4:46 am, 4/25/22 |
| Deyvison De Los Santos | Chinballs | DROP | to FA | 9:32 pm, 4/24/22 |