| Player | Team | Action | Details | |
|---|---|---|---|---|
| Reiver Sanmartin | Bullet Club | DROP | to FA | 1:35 am, 4/20/22 |
| Rich Hill | The Bluth Company | DROP | to FA | 9:28 pm, 4/19/22 |
| Seth Brown | Monk's Café | DROP | to FA | 6:48 pm, 4/19/22 |
| Ty Madden | The Bluth Company | DROP | to FA | 1:18 pm, 4/19/22 |
| Peyton Battenfield | Monk's Café | DROP | to FA | 12:39 pm, 4/19/22 |
| Anthony Garcia | The Bluth Company | DROP | to FA | 12:36 pm, 4/19/22 |
| Wilmer Flores | Supreme Clientele | DROP | to FA | 10:44 am, 4/19/22 |
| Zack Collins | Supreme Clientele | DROP | to FA | 10:44 am, 4/19/22 |
| Chad Green | Monk's Café | DROP | to FA | 6:51 am, 4/19/22 |
| Zach Thompson | Chinballs | DROP | to FA | 10:19 pm, 4/18/22 |
| Christian Encarnacion-Strand | The Bluth Company | DROP | to FA | 8:19 pm, 4/18/22 |
| Aaron Schunk | Shaolin Schmeckles | DROP | to FA | 1:17 pm, 4/18/22 |
| Jose Suarez | The Bluth Company | DROP | to FA | 10:29 am, 4/18/22 |
| Tommy Romero | Geckos | DROP | to FA | 10:25 am, 4/18/22 |
| Clay Holmes | The Bluth Company | DROP | to FA | 6:22 pm, 4/17/22 |
| Cristian Pache | Supreme Clientele | DROP | to FA | 5:46 pm, 4/17/22 |
| Omar Narvaez | Supreme Clientele | DROP | to FA | 5:46 pm, 4/17/22 |
| Jonathan Loaisiga | Chinballs | DROP | to FA | 2:42 pm, 4/17/22 |
| Mike Zunino | Cowboys From Hell | DROP | to FA | 2:35 pm, 4/17/22 |
| Jose Iglesias | Geckos | DROP | to FA | 2:04 pm, 4/17/22 |
| Miguel Cabrera | Geckos | DROP | to FA | 2:03 pm, 4/17/22 |
| Josh Rogers | Undead Rabbits | DROP | to FA | 11:18 am, 4/17/22 |
| Bryse Wilson | Undead Rabbits | DROP | to FA | 11:18 am, 4/17/22 |
| Nick Solak | Undead Rabbits | DROP | to FA | 11:17 am, 4/17/22 |
| Andrew McCutchen | The Red Barons | DROP | to FA | 6:44 am, 4/17/22 |