| Player | Team | Action | Details | |
|---|---|---|---|---|
| Tyler Anderson | Cowboys From Hell | DROP | to FA | 4:01 pm, 4/13/21 |
| Matt Harvey | Cowboys From Hell | DROP | to FA | 1:21 pm, 4/13/21 |
| Ross Stripling | Chinballs | DROP | to FA | 12:48 pm, 4/13/21 |
| Victor Caratini | Bullet Club | DROP | to FA | 12:08 pm, 4/13/21 |
| Mitch Moreland | Geckos | DROP | to FA | 4:44 pm, 4/12/21 |
| Josh Fuentes | Geckos | DROP | to FA | 4:44 pm, 4/12/21 |
| Elvis Andrus | Scranton Yankees | DROP | to FA | 2:54 pm, 4/12/21 |
| Kevin Ginkel | Shaolin Schmeckles | DROP | to FA | 1:19 pm, 4/12/21 |
| Gregory Soto | Supreme Clientele | DROP | to FA | 10:31 pm, 4/11/21 |
| Brandon Bielak | Purple Cobras | DROP | to FA | 7:53 pm, 4/11/21 |
| William Contreras | The Bluth Company | DROP | to FA | 4:21 pm, 4/11/21 |
| Jonah Heim | Shaolin Schmeckles | DROP | to FA | 12:59 pm, 4/11/21 |
| Jake Diekman | Shaolin Schmeckles | DROP | to FA | 6:46 pm, 4/10/21 |
| Starlin Castro | Undead Rabbits | DROP | to FA | 1:06 pm, 4/10/21 |
| Adam Ottavino | Undead Rabbits | DROP | to FA | 1:06 pm, 4/10/21 |
| Michael Tauchman | Bullet Club | DROP | to FA | 1:00 pm, 4/10/21 |
| Connor Brogdon | Purple Cobras | DROP | to FA | 10:59 pm, 4/9/21 |
| Bobby Bradley | Bullet Club | DROP | to FA | 12:45 pm, 4/9/21 |
| Jackie Bradley Jr | Geckos | DROP | to FA | 10:50 am, 4/9/21 |
| David Bote | Geckos | DROP | to FA | 10:50 am, 4/9/21 |
| Caleb Smith | Chinballs | DROP | to FA | 8:14 pm, 4/8/21 |
| Brandon Williamson | Geckos | DROP | to FA | 1:06 pm, 4/8/21 |
| Jay Bruce | Geckos | DROP | to FA | 10:35 am, 4/8/21 |
| Trevor May | Geckos | DROP | to FA | 10:34 am, 4/8/21 |
| Andrew Stevenson | Cowboys From Hell | DROP | to FA | 10:03 am, 4/8/21 |