| Player | Team | Action | Details | |
|---|---|---|---|---|
| Justin Upton | Scranton Yankees | DROP | to FA | 2:14 pm, 4/2/21 |
| Rougned Odor | Scranton Yankees | DROP | to FA | 2:13 pm, 4/2/21 |
| J.B. Bukauskas | Purple Cobras | DROP | to FA | 9:03 am, 4/2/21 |
| Colin Barber | The Bluth Company | DROP | to FA | 11:23 pm, 4/1/21 |
| Gregory Santos | The Bluth Company | DROP | to FA | 7:32 pm, 4/1/21 |
| Ronald Guzman | Bullet Club | DROP | to FA | 3:05 pm, 4/1/21 |
| Bobby Bradley | Bullet Club | DROP | to FA | 2:55 pm, 4/1/21 |
| Sherten Apostel | Bullet Club | DROP | to FA | 11:47 am, 4/1/21 |
| Michael Fulmer | Bullet Club | DROP | to FA | 11:43 am, 4/1/21 |
| Alec Mills | Bullet Club | DROP | to FA | 11:43 am, 4/1/21 |
| Nick Ahmed | Jon Voight's Car | DROP | to FA | 11:19 am, 4/1/21 |
| Adolis Garcia | Purple Cobras | DROP | to FA | 11:15 am, 4/1/21 |
| Lewin Diaz | Bridge Four | DROP | to FA | 10:59 am, 4/1/21 |
| Ivan Nova | Bridge Four | DROP | to FA | 10:51 am, 4/1/21 |
| Jackie Bradley Jr | Kimble's Kids | DROP | to FA | 10:46 am, 4/1/21 |
| Kirby Yates | Ye Olde Tom Toolshed | DROP | to FA | 10:16 am, 4/1/21 |
| Victor Reyes | Chinballs | DROP | to FA | 10:01 am, 4/1/21 |
| Drew Strotman | The Bluth Company | DROP | to FA | 1:30 am, 4/1/21 |
| Clayton Beeter | The Bluth Company | DROP | to FA | 1:08 am, 4/1/21 |
| Blake Hunt | The Bluth Company | DROP | to FA | 12:38 am, 4/1/21 |
| Wilson Ramos | Cowboys From Hell | DROP | to FA | 7:59 pm, 3/31/21 |
| Jared Oliva | Chinballs | DROP | to FA | 6:25 pm, 3/31/21 |
| Lenny Torres | Chinballs | DROP | to FA | 5:26 pm, 3/31/21 |
| Jay Bruce | Shaolin Schmeckles | DROP | to FA | 4:35 pm, 3/31/21 |
| Kyle Freeland | Supreme Clientele | DROP | to FA | 4:30 pm, 3/31/21 |