| Player | Team | Action | Details | |
|---|---|---|---|---|
| Yosver Zulueta | The Bluth Company | ADD | to AAA | 5:24 pm, 5/5/22 |
| Jonah Heim | Supreme Clientele | ADD | to MLB | 3:24 pm, 5/5/22 |
| Martin Perez | Supreme Clientele | ADD | to MLB | 3:23 pm, 5/5/22 |
| Brock Burke | Ye Olde Tom Toolshed | ADD | to MLB | 12:34 pm, 5/5/22 |
| Cesar Hernandez | Geckos | ADD | to MLB | 10:20 am, 5/5/22 |
| Jonathan Aranda | The Bluth Company | ADD | to AA | 11:51 pm, 5/4/22 |
| Michael Massey | Geckos | ADD | to AAA | 7:11 pm, 5/4/22 |
| Luis Rodriguez | Geckos | ADD | to A | 1:33 pm, 5/4/22 |
| Michael Massey | Geckos | ADD | to AAA | 1:06 pm, 5/4/22 |
| Christian Encarnacion-Strand | Chinballs | ADD | to AAA | 11:21 am, 5/4/22 |
| Chad Pinder | Chinballs | ADD | to MLB | 11:12 am, 5/4/22 |
| Keegan Thompson | Undead Rabbits | ADD | to MLB | 9:48 am, 5/4/22 |
| Drew Romo | The Bluth Company | ADD | to AAA | 9:47 am, 5/4/22 |
| Jose Butto | Geckos | ADD | to AAA | 9:46 am, 5/4/22 |
| Edward Olivares | Undead Rabbits | ADD | to MLB | 7:02 am, 5/4/22 |
| Brandon Drury | The Red Barons | ADD | to MLB | 5:25 pm, 5/3/22 |
| Alex Faedo | Cowboys From Hell | ADD | to MLB | 5:13 pm, 5/3/22 |
| Andy Ibanez | The Red Barons | ADD | to MLB | 3:48 pm, 5/3/22 |
| Jon Berti | Bullet Club | ADD | to MLB | 2:20 pm, 5/3/22 |
| Duane Underwood | Undead Rabbits | ADD | to AAA | 8:33 am, 5/3/22 |
| Trevor Stephan | The Bluth Company | ADD | to MLB | 6:45 am, 5/3/22 |
| Huascar Ynoa | The Bluth Company | ADD | to NA | 6:44 am, 5/3/22 |
| Yadiel Hernandez | The Bluth Company | ADD | to MLB | 11:46 pm, 5/2/22 |
| Ross Stripling | The Bluth Company | ADD | to MLB | 11:44 pm, 5/2/22 |
| Jose Trevino | Monk's Café | ADD | to MLB | 5:04 pm, 5/2/22 |