| Player | Team | Action | Details | |
|---|---|---|---|---|
| Royber Salinas | Monk's Café | ADD | to A | 12:39 pm, 4/19/22 |
| J.P. Feyereisen | Monk's Café | ADD | to MLB | 12:37 pm, 4/19/22 |
| Nick Nastrini | The Bluth Company | ADD | to A | 12:36 pm, 4/19/22 |
| Max Stassi | Supreme Clientele | ADD | to MLB | 10:44 am, 4/19/22 |
| Adael Amador | Chinballs | ADD | to A | 10:25 pm, 4/18/22 |
| Chad Green | Monk's Café | ADD | to MLB | 9:48 pm, 4/18/22 |
| Alex Ramirez | The Bluth Company | ADD | to A | 8:19 pm, 4/18/22 |
| Kyle Stowers | Undead Rabbits | ADD | to MLB | 7:00 pm, 4/18/22 |
| Ceddanne Rafaela | Shaolin Schmeckles | ADD | to A | 6:59 pm, 4/18/22 |
| Emmanuel Rodriguez | Shaolin Schmeckles | ADD | to A | 6:59 pm, 4/18/22 |
| Michael Chavis | Geckos | ADD | to MLB | 10:25 am, 4/18/22 |
| Christian Encarnacion-Strand | The Bluth Company | ADD | to AAA | 10:13 am, 4/18/22 |
| Cristian Pache | Cowboys From Hell | ADD | to MLB | 9:13 pm, 4/17/22 |
| Josh Fleming | The Bluth Company | ADD | to MLB | 6:22 pm, 4/17/22 |
| Brad Keller | Supreme Clientele | ADD | to MLB | 5:47 pm, 4/17/22 |
| Wilmer Flores | Supreme Clientele | ADD | to MLB | 5:47 pm, 4/17/22 |
| Zack Collins | Supreme Clientele | ADD | to MLB | 5:46 pm, 4/17/22 |
| Corbin Martin | Supreme Clientele | ADD | to MLB | 5:46 pm, 4/17/22 |
| Gordon Graceffo | Chinballs | ADD | to A | 2:40 pm, 4/17/22 |
| Thairo Estrada | The Bluth Company | ADD | to MLB | 2:05 pm, 4/17/22 |
| Nick Solak | Geckos | ADD | to MLB | 2:04 pm, 4/17/22 |
| Erick Fedde | Geckos | ADD | to MLB | 2:04 pm, 4/17/22 |
| Clay Holmes | The Bluth Company | ADD | to MLB | 1:24 pm, 4/17/22 |
| Bruce Zimmermann | Undead Rabbits | ADD | to MLB | 11:19 am, 4/17/22 |
| Michael Wacha | Undead Rabbits | ADD | to MLB | 11:18 am, 4/17/22 |