| Player | Team | Action | Details | |
|---|---|---|---|---|
| Dominic Smith | Geckos | ADD | to MLB | 10:05 am, 5/2/22 |
| Kendall Graveman | Ye Olde Tom Toolshed | ADD | to MLB | 9:24 am, 5/2/22 |
| Santiago Espinal | Ye Olde Tom Toolshed | ADD | to MLB | 9:23 am, 5/2/22 |
| Jalen Beeks | The Red Barons | ADD | to MLB | 8:46 am, 5/2/22 |
| Kyle Higashioka | Monk's Café | ADD | to MLB | 1:47 pm, 5/1/22 |
| Travis Demeritte | Cowboys From Hell | ADD | to MLB | 9:31 am, 5/1/22 |
| Jeimer Candelario | The Red Barons | ADD | to MLB | 6:33 am, 5/1/22 |
| Brice Turang | The Bluth Company | ADD | to AAA | 9:53 pm, 4/30/22 |
| Taylor Walls | The Bluth Company | ADD | to AAA | 9:43 pm, 4/30/22 |
| Freddy Tarnok | The Bluth Company | ADD | to AAA | 9:19 pm, 4/30/22 |
| Garrett Cooper | Supreme Clientele | ADD | to MLB | 7:41 pm, 4/30/22 |
| Gio Urshela | Monk's Café | ADD | to MLB | 10:40 am, 4/30/22 |
| Maikel Franco | The Red Barons | ADD | to MLB | 7:28 am, 4/30/22 |
| Paul Blackburn | Bullet Club | ADD | to MLB | 10:55 pm, 4/29/22 |
| Kris Bubic | Bullet Club | ADD | to MLB | 10:53 pm, 4/29/22 |
| Joe Ross | The Red Barons | ADD | to MLB | 6:43 pm, 4/29/22 |
| Yosver Zulueta | The Bluth Company | ADD | to AAA | 3:59 pm, 4/29/22 |
| Martin Perez | The Bluth Company | ADD | to MLB | 11:58 am, 4/29/22 |
| Erik Swanson | The Bluth Company | ADD | to MLB | 11:53 am, 4/29/22 |
| Esteury Ruiz | Ye Olde Tom Toolshed | ADD | to AA | 6:36 pm, 4/28/22 |
| Brian Anderson | Geckos | ADD | to MLB | 3:50 pm, 4/28/22 |
| Odubel Herrera | Geckos | ADD | to MLB | 3:49 pm, 4/28/22 |
| Paul Sewald | The Bluth Company | ADD | to MLB | 2:07 pm, 4/28/22 |
| Nick Nastrini | The Bluth Company | ADD | to A | 2:07 pm, 4/28/22 |
| Brock Burke | The Bluth Company | ADD | to AAA | 2:04 pm, 4/28/22 |