| Player | Team | Action | Details | |
|---|---|---|---|---|
| Hansel Robles | Shaolin Schmeckles | ADD | to MLB | 4:15 pm, 4/16/22 |
| Kyle Bradish | The Bluth Company | ADD | to AAA | 3:10 pm, 4/16/22 |
| Masyn Winn | The Bluth Company | ADD | to AA | 2:12 pm, 4/16/22 |
| Felix Valerio | The Bluth Company | ADD | to AAA | 12:34 pm, 4/16/22 |
| Michael McGreevy | Chinballs | ADD | to AA | 12:33 pm, 4/16/22 |
| Miguel Cabrera | Geckos | ADD | to MLB | 10:24 am, 4/16/22 |
| Jake Burger | Geckos | ADD | to MLB | 10:24 am, 4/16/22 |
| Dan Vogelbach | Geckos | ADD | to MLB | 5:14 pm, 4/15/22 |
| Andrew McCutchen | The Red Barons | ADD | to MLB | 12:03 pm, 4/15/22 |
| Michael King | Kimble's Kids | ADD | to MLB | 11:03 am, 4/15/22 |
| Jordan Lyles | Kimble's Kids | ADD | to MLB | 11:01 am, 4/15/22 |
| Aaron Schunk | Shaolin Schmeckles | ADD | to A | 9:57 am, 4/15/22 |
| Alex De Jesus | Shaolin Schmeckles | ADD | to A | 9:56 am, 4/15/22 |
| Jonathan Villar | The Red Barons | ADD | to MLB | 8:43 am, 4/15/22 |
| Taylor Hearn | Bullet Club | ADD | to AAA | 12:54 am, 4/15/22 |
| Jose Iglesias | Geckos | ADD | to MLB | 7:20 pm, 4/14/22 |
| J.P. Crawford | The Red Barons | ADD | to MLB | 11:39 am, 4/14/22 |
| Elvis Andrus | The Red Barons | ADD | to MLB | 6:44 am, 4/14/22 |
| Cooper Hummel | Monk's Café | ADD | to AAA | 6:24 am, 4/14/22 |
| Tony Kemp | The Red Barons | ADD | to MLB | 6:19 am, 4/14/22 |
| Isaac Paredes | The Red Barons | ADD | to AAA | 6:19 am, 4/14/22 |
| Alex Binelas | The Bluth Company | ADD | to A | 11:45 pm, 4/13/22 |
| Gabriel Arias | The Bluth Company | ADD | to AAA | 11:29 pm, 4/13/22 |
| Anthony Garcia | The Bluth Company | ADD | to A | 9:42 pm, 4/13/22 |
| Anthony Solometo | Jon Voight's Car | ADD | to A | 9:56 am, 4/13/22 |