| Player | Team | Action | Details | |
|---|---|---|---|---|
| Hayden Wesneski | Bullet Club | ADD | to AAA | 11:02 pm, 4/7/22 |
| Christian Walker | Cowboys From Hell | ADD | to MLB | 5:04 pm, 4/7/22 |
| Aristides Aquino | Bullet Club | ADD | to MLB | 5:04 pm, 4/7/22 |
| Garrett Hampson | Ye Olde Tom Toolshed | ADD | to MLB | 3:49 pm, 4/7/22 |
| Tyler Duffey | Monk's Café | ADD | to MLB | 3:47 pm, 4/7/22 |
| Josh Harrison | Monk's Café | ADD | to MLB | 3:44 pm, 4/7/22 |
| Aledmys Diaz | Shaolin Schmeckles | ADD | to MLB | 2:31 pm, 4/7/22 |
| Collin McHugh | The Bluth Company | ADD | to MLB | 1:02 pm, 4/7/22 |
| Reiver Sanmartin | Bullet Club | ADD | to AAA | 10:48 am, 4/7/22 |
| Jonathan Aranda | The Bluth Company | ADD | to MLB | 9:18 am, 4/7/22 |
| Joshua Baez | Bullet Club | ADD | to MLB | 7:00 pm, 4/6/22 |
| Daniel Bard | The Red Barons | ADD | to MLB | 4:20 pm, 4/6/22 |
| Darin Ruf | The Red Barons | ADD | to MLB | 9:33 am, 4/6/22 |
| Deyvison De Los Santos | Chinballs | ADD | to A | 10:29 pm, 4/5/22 |
| Brice Turang | The Bluth Company | ADD | to AA | 10:28 pm, 4/5/22 |
| Vaughn Grissom | Geckos | ADD | to A | 10:28 pm, 4/5/22 |
| Matthew Frazier | The Bluth Company | ADD | to AA | 10:27 pm, 4/5/22 |
| Jose Ramos | The Bluth Company | ADD | to A | 10:24 pm, 4/5/22 |
| Freddy Tarnok | The Bluth Company | ADD | to AA | 10:24 pm, 4/5/22 |
| Jose Tena | Geckos | ADD | to A | 10:22 pm, 4/5/22 |
| Jordan Wicks | Geckos | ADD | to AA | 10:21 pm, 4/5/22 |
| Joshua Mears | Geckos | ADD | to A | 10:19 pm, 4/5/22 |
| Omar Narvaez | Supreme Clientele | ADD | to MLB | 4:34 pm, 4/5/22 |
| Aaron Zavala | Ye Olde Tom Toolshed | ADD | to A | 12:15 pm, 4/5/22 |
| Connor Norby | Ye Olde Tom Toolshed | ADD | to A | 12:15 pm, 4/5/22 |