| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jorge Lopez | Monk's Café | ADD | to MLB | 7:20 am, 4/9/22 |
| Danny Duffy | Cowboys From Hell | ADD | to MLB | 6:51 am, 4/9/22 |
| Ken Giles | Cowboys From Hell | ADD | to MLB | 6:51 am, 4/9/22 |
| Gio Urshela | Monk's Café | ADD | to MLB | 6:40 am, 4/9/22 |
| Cooper Hummel | The Bluth Company | ADD | to AAA | 8:04 pm, 4/8/22 |
| Victor Acosta | Bullet Club | ADD | to A | 8:03 pm, 4/8/22 |
| Yandy Diaz | Geckos | ADD | to MLB | 12:55 pm, 4/8/22 |
| Brusdar Graterol | Bullet Club | ADD | to MLB | 12:51 pm, 4/8/22 |
| Robinson Cano | Cowboys From Hell | ADD | to MLB | 12:14 pm, 4/8/22 |
| Eric Hosmer | Kimble's Kids | ADD | to MLB | 12:06 pm, 4/8/22 |
| Thairo Estrada | The Bluth Company | ADD | to MLB | 9:39 am, 4/8/22 |
| D.J. Herz | Shaolin Schmeckles | ADD | to A | 12:23 am, 4/8/22 |
| Hyun-il Choi | Shaolin Schmeckles | ADD | to A | 12:20 am, 4/8/22 |
| Joey Estes | Shaolin Schmeckles | ADD | to A | 12:17 am, 4/8/22 |
| Sam Huff | Shaolin Schmeckles | ADD | to AA | 11:58 pm, 4/7/22 |
| Hayden Wesneski | Bullet Club | ADD | to AAA | 11:02 pm, 4/7/22 |
| Christian Walker | Cowboys From Hell | ADD | to MLB | 5:04 pm, 4/7/22 |
| Aristides Aquino | Bullet Club | ADD | to MLB | 5:04 pm, 4/7/22 |
| Garrett Hampson | Ye Olde Tom Toolshed | ADD | to MLB | 3:49 pm, 4/7/22 |
| Tyler Duffey | Monk's Café | ADD | to MLB | 3:47 pm, 4/7/22 |
| Josh Harrison | Monk's Café | ADD | to MLB | 3:44 pm, 4/7/22 |
| Aledmys Diaz | Shaolin Schmeckles | ADD | to MLB | 2:31 pm, 4/7/22 |
| Collin McHugh | The Bluth Company | ADD | to MLB | 1:02 pm, 4/7/22 |
| Reiver Sanmartin | Bullet Club | ADD | to AAA | 10:48 am, 4/7/22 |
| Jonathan Aranda | The Bluth Company | ADD | to MLB | 9:18 am, 4/7/22 |