| Player | Team | Action | Details | |
|---|---|---|---|---|
| Joshua Baez | Bullet Club | ADD | to MLB | 7:00 pm, 4/6/22 |
| Daniel Bard | The Red Barons | ADD | to MLB | 4:20 pm, 4/6/22 |
| Darin Ruf | The Red Barons | ADD | to MLB | 9:33 am, 4/6/22 |
| Deyvison De Los Santos | Chinballs | ADD | to A | 10:29 pm, 4/5/22 |
| Brice Turang | The Bluth Company | ADD | to AA | 10:28 pm, 4/5/22 |
| Vaughn Grissom | Geckos | ADD | to A | 10:28 pm, 4/5/22 |
| Matthew Frazier | The Bluth Company | ADD | to AA | 10:27 pm, 4/5/22 |
| Jose Ramos | The Bluth Company | ADD | to A | 10:24 pm, 4/5/22 |
| Freddy Tarnok | The Bluth Company | ADD | to AA | 10:24 pm, 4/5/22 |
| Jose Tena | Geckos | ADD | to A | 10:22 pm, 4/5/22 |
| Jordan Wicks | Geckos | ADD | to AA | 10:21 pm, 4/5/22 |
| Joshua Mears | Geckos | ADD | to A | 10:19 pm, 4/5/22 |
| Omar Narvaez | Supreme Clientele | ADD | to MLB | 4:34 pm, 4/5/22 |
| Aaron Zavala | Ye Olde Tom Toolshed | ADD | to A | 12:15 pm, 4/5/22 |
| Connor Norby | Ye Olde Tom Toolshed | ADD | to A | 12:15 pm, 4/5/22 |
| Colson Montgomery | Ye Olde Tom Toolshed | ADD | to A | 12:14 pm, 4/5/22 |
| Diego Castillo | Cowboys From Hell | ADD | to MLB | 12:12 pm, 4/5/22 |
| Andrew McCutchen | The Red Barons | ADD | to MLB | 12:04 pm, 4/5/22 |
| Carter Kieboom | The Red Barons | ADD | to MLB | 12:03 pm, 4/5/22 |
| Andres Munoz | Undead Rabbits | ADD | to AA | 10:39 am, 4/5/22 |
| Ryne Nelson | The Bluth Company | ADD | to MLB | 12:49 am, 4/5/22 |
| Michael Fulmer | Monk's Café | ADD | to MLB | 11:20 pm, 4/4/22 |
| Chris Rodriguez | Monk's Café | ADD | to AAA | 11:19 pm, 4/4/22 |
| Kevin Smith | Ye Olde Tom Toolshed | ADD | to MLB | 11:18 pm, 4/4/22 |
| Domingo German | The Bluth Company | ADD | to MLB | 11:16 pm, 4/4/22 |