| Player | Team | Action | Details | |
|---|---|---|---|---|
| Tyler Naquin | Ye Olde Tom Toolshed | ADD | to MLB | 9:50 am, 10/1/21 |
| Buddy Kennedy | Shaolin Schmeckles | ADD | to AA | 3:38 pm, 9/30/21 |
| Camilo Doval | Chinballs | ADD | to MLB | 3:22 pm, 9/30/21 |
| Andy Ibanez | Purple Cobras | ADD | to MLB | 10:17 pm, 9/29/21 |
| Lou Trivino | Purple Cobras | ADD | to MLB | 7:34 am, 9/29/21 |
| J.P. Crawford | The Red Barons | ADD | to MLB | 9:34 pm, 9/28/21 |
| Corey Knebel | Chinballs | ADD | to MLB | 6:54 pm, 9/28/21 |
| Elias Diaz | Purple Cobras | ADD | to MLB | 8:59 am, 9/28/21 |
| Ryan Yarbrough | The Bluth Company | ADD | to MLB | 12:59 am, 9/28/21 |
| Sam Long | The Bluth Company | ADD | to MLB | 12:57 am, 9/28/21 |
| Harrison Bader | Chinballs | ADD | to MLB | 12:03 pm, 9/27/21 |
| Lucas Sims | Purple Cobras | ADD | to MLB | 2:48 am, 9/27/21 |
| Matt Barnes | Undead Rabbits | ADD | to MLB | 12:31 am, 9/27/21 |
| Connor Seabold | Purple Cobras | ADD | to AAA | 9:26 pm, 9/26/21 |
| Sam Long | Purple Cobras | ADD | to AAA | 8:46 pm, 9/26/21 |
| Sam Hilliard | Purple Cobras | ADD | to MLB | 5:06 pm, 9/26/21 |
| Lewin Diaz | The Red Barons | ADD | to AAA | 10:45 am, 9/26/21 |
| Eli Morgan | Purple Cobras | ADD | to AAA | 1:18 am, 9/26/21 |
| Max Kranick | Chinballs | ADD | to AAA | 11:53 pm, 9/24/21 |
| Jon Heasley | Chinballs | ADD | to AAA | 11:46 pm, 9/24/21 |
| Paolo Espino | Purple Cobras | ADD | to MLB | 3:09 am, 9/24/21 |
| Josh Staumont | Shaolin Schmeckles | ADD | to MLB | 5:05 pm, 9/23/21 |
| Tommy La Stella | The Bluth Company | ADD | to MLB | 2:15 pm, 9/23/21 |
| Tanner Rainey | The Red Barons | ADD | to MLB | 1:04 pm, 9/23/21 |
| J.A. Happ | Purple Cobras | ADD | to MLB | 10:06 am, 9/23/21 |