| Player | Team | Action | Details | |
|---|---|---|---|---|
| Vinnie Pasquantino | The Bluth Company | ADD | to AAA | 11:43 pm, 9/21/21 |
| Gabriel Arias | The Bluth Company | ADD | to AAA | 10:20 pm, 9/21/21 |
| Robinson Cano | The Bluth Company | ADD | to MLB | 10:16 pm, 9/21/21 |
| Paul Sewald | The Bluth Company | ADD | to MLB | 10:16 pm, 9/21/21 |
| Jeremy Pena | Geckos | ADD | to AA | 10:39 am, 9/21/21 |
| Yadier Molina | Purple Cobras | ADD | to MLB | 3:53 pm, 9/20/21 |
| Wily Peralta | Chinballs | ADD | to MLB | 1:27 pm, 9/20/21 |
| Collin McHugh | The Red Barons | ADD | to MLB | 10:24 am, 9/20/21 |
| Jon Heasley | The Bluth Company | ADD | to AAA | 1:25 pm, 9/17/21 |
| Micker Adolfo | The Red Barons | ADD | to AA | 8:51 am, 9/17/21 |
| Omar Narvaez | The Red Barons | ADD | to MLB | 8:48 am, 9/17/21 |
| Vincent Velasquez | The Bluth Company | ADD | to AAA | 2:15 pm, 9/16/21 |
| Eli Morgan | The Bluth Company | ADD | to AAA | 8:51 am, 9/16/21 |
| Griffin Jax | The Bluth Company | ADD | to MLB | 7:21 pm, 9/15/21 |
| Corey Kluber | Bullet Club | ADD | to MLB | 11:52 am, 9/15/21 |
| Lewin Diaz | Purple Cobras | ADD | to AAA | 7:20 am, 9/15/21 |
| Kyle Isbel | Purple Cobras | ADD | to AA | 6:30 am, 9/15/21 |
| Elias Diaz | Purple Cobras | ADD | to MLB | 10:15 pm, 9/14/21 |
| Janson Junk | The Bluth Company | ADD | to AAA | 10:06 pm, 9/14/21 |
| Chris Stratton | The Red Barons | ADD | to MLB | 6:43 pm, 9/14/21 |
| Dietrich Enns | Purple Cobras | ADD | to AAA | 12:59 pm, 9/14/21 |
| Jake Woodford | Purple Cobras | ADD | to AAA | 6:49 am, 9/13/21 |
| Bryan De La Cruz | Purple Cobras | ADD | to AAA | 6:51 pm, 9/11/21 |
| Ian Seymour | Chinballs | ADD | to AAA | 6:50 pm, 9/11/21 |
| Humberto Castellanos | The Bluth Company | ADD | to AAA | 6:49 pm, 9/11/21 |