| Player | Team | Action | Details | |
|---|---|---|---|---|
| Peyton Battenfield | Undead Rabbits | ADD | to AA | 3:16 pm, 5/8/22 |
| Dax Fulton | The Bluth Company | ADD | to AA | 1:33 am, 5/7/22 |
| Francisco Mejia | Scranton Yankees | ADD | to MLB | 8:33 pm, 5/6/22 |
| Dan Jansen | Scranton Yankees | ADD | to MLB | 8:33 pm, 5/6/22 |
| Anthony Bass | Scranton Yankees | ADD | to MLB | 8:32 pm, 5/6/22 |
| Jose Quintana | Scranton Yankees | ADD | to MLB | 8:32 pm, 5/6/22 |
| Vincent Velasquez | Scranton Yankees | ADD | to MLB | 8:32 pm, 5/6/22 |
| Drew Smyly | Scranton Yankees | ADD | to MLB | 8:32 pm, 5/6/22 |
| Dillon Overton | Scranton Yankees | ADD | to MLB | 8:32 pm, 5/6/22 |
| Marco Raya | Jon Voight's Car | ADD | to A | 4:28 pm, 5/6/22 |
| Andrew McCutchen | Shaolin Schmeckles | ADD | to MLB | 3:32 pm, 5/6/22 |
| Dan Vogelbach | The Bluth Company | ADD | to MLB | 3:23 pm, 5/6/22 |
| Edwin Arroyo | The Bluth Company | ADD | to A | 2:19 pm, 5/6/22 |
| Ross Stripling | Monk's Café | ADD | to MLB | 5:53 am, 5/6/22 |
| A.J. Puk | Cowboys From Hell | ADD | to MLB | 12:24 am, 5/6/22 |
| Yosver Zulueta | The Bluth Company | ADD | to AAA | 5:24 pm, 5/5/22 |
| Jonah Heim | Supreme Clientele | ADD | to MLB | 3:24 pm, 5/5/22 |
| Martin Perez | Supreme Clientele | ADD | to MLB | 3:23 pm, 5/5/22 |
| Brock Burke | Ye Olde Tom Toolshed | ADD | to MLB | 12:34 pm, 5/5/22 |
| Cesar Hernandez | Geckos | ADD | to MLB | 10:20 am, 5/5/22 |
| Jonathan Aranda | The Bluth Company | ADD | to AA | 11:51 pm, 5/4/22 |
| Michael Massey | Geckos | ADD | to AAA | 7:11 pm, 5/4/22 |
| Luis Rodriguez | Geckos | ADD | to A | 1:33 pm, 5/4/22 |
| Michael Massey | Geckos | ADD | to AAA | 1:06 pm, 5/4/22 |
| Christian Encarnacion-Strand | Chinballs | ADD | to AAA | 11:21 am, 5/4/22 |