| Player | Team | Action | Details | |
|---|---|---|---|---|
| Marco Raya | The Bluth Company | ADD | to A | 8:09 am, 4/27/22 |
| Craig Stammen | Nixon's Nasty Ninjas | ADD | to MLB | 9:36 pm, 4/26/22 |
| Drew Smith | Geckos | ADD | to MLB | 5:28 pm, 4/26/22 |
| Miguel Andujar | Cowboys From Hell | ADD | to MLB | 5:26 pm, 4/26/22 |
| Andrew Abbott | Geckos | ADD | to AA | 2:10 pm, 4/26/22 |
| Devin Williams | The Bluth Company | ADD | to MLB | 1:02 pm, 4/26/22 |
| Dany Jimenez | Shaolin Schmeckles | ADD | to MLB | 11:32 am, 4/26/22 |
| Michael Chavis | Bullet Club | ADD | to MLB | 11:26 am, 4/26/22 |
| Chris Stratton | Shaolin Schmeckles | ADD | to MLB | 11:09 am, 4/26/22 |
| Michael King | The Bluth Company | ADD | to MLB | 11:01 am, 4/26/22 |
| Hector Neris | Kimble's Kids | ADD | to MLB | 10:49 am, 4/26/22 |
| Christian Encarnacion-Strand | Chinballs | ADD | to A | 10:20 am, 4/26/22 |
| Alex Binelas | Chinballs | ADD | to A | 3:56 am, 4/26/22 |
| Dominic Smith | Geckos | ADD | to MLB | 1:05 pm, 4/25/22 |
| Cesar Prieto | The Bluth Company | ADD | to AAA | 1:04 pm, 4/25/22 |
| Griff McGarry | The Bluth Company | ADD | to AA | 1:01 pm, 4/25/22 |
| Brandon Walter | The Bluth Company | ADD | to AA | 12:59 pm, 4/25/22 |
| Jake Junis | Ye Olde Tom Toolshed | ADD | to MLB | 11:24 am, 4/25/22 |
| Ji-Man Choi | Supreme Clientele | ADD | to MLB | 11:02 am, 4/25/22 |
| Johan Camargo | Supreme Clientele | ADD | to MLB | 11:02 am, 4/25/22 |
| Kyle Freeland | Supreme Clientele | ADD | to MLB | 11:01 am, 4/25/22 |
| Yandy Diaz | Supreme Clientele | ADD | to MLB | 11:01 am, 4/25/22 |
| Deyvison De Los Santos | Bullet Club | ADD | to MLB | 10:04 am, 4/25/22 |
| Joey Wendle | Chinballs | ADD | to MLB | 4:46 am, 4/25/22 |
| Christian Encarnacion-Strand | Chinballs | ADD | to AA | 9:32 pm, 4/24/22 |