| Player | Team | Action | Details | |
|---|---|---|---|---|
| Scott Kazmir | The Bluth Company | ADD | to AAA | 8:18 pm, 5/21/21 |
| Miguel Vargas | Chinballs | ADD | to A | 3:26 pm, 5/21/21 |
| Vincent Velasquez | Supreme Clientele | ADD | to MLB | 2:47 pm, 5/21/21 |
| Jorge Lopez | Supreme Clientele | ADD | to MLB | 2:46 pm, 5/21/21 |
| Anthony Kay | Supreme Clientele | ADD | to MLB | 2:46 pm, 5/21/21 |
| Randy Dobnak | Supreme Clientele | ADD | to MLB | 2:44 pm, 5/21/21 |
| Patrick Bailey | The Bluth Company | ADD | to AAA | 1:23 pm, 5/21/21 |
| Michael Baumann | The Bluth Company | ADD | to AAA | 1:22 pm, 5/21/21 |
| Brian Rey | Ye Olde Tom Toolshed | ADD | to AAA | 12:49 pm, 5/21/21 |
| Spencer Strider | Shaolin Schmeckles | ADD | to AAA | 12:37 pm, 5/21/21 |
| Jose Rojas | Shaolin Schmeckles | ADD | to MLB | 12:37 pm, 5/21/21 |
| Aaron Ashby | Undead Rabbits | ADD | to AAA | 11:43 am, 5/21/21 |
| Yadiel Hernandez | The Bluth Company | ADD | to AAA | 12:21 am, 5/21/21 |
| Aaron Ashby | Undead Rabbits | ADD | to AAA | 7:10 pm, 5/20/21 |
| Domingo Leyba | Shaolin Schmeckles | ADD | to AAA | 6:52 pm, 5/20/21 |
| Wilson Ramos | Bridge Four | ADD | to MLB | 3:59 pm, 5/20/21 |
| Miguel Rojas | Shaolin Schmeckles | ADD | to MLB | 12:06 pm, 5/20/21 |
| Yonathan Daza | Cowboys From Hell | ADD | to MLB | 10:07 am, 5/20/21 |
| Alex Cobb | Bullet Club | ADD | to MLB | 8:10 am, 5/20/21 |
| Tyler Ivey | Purple Cobras | ADD | to AAA | 7:48 am, 5/20/21 |
| Martin Perez | Undead Rabbits | ADD | to MLB | 12:01 am, 5/20/21 |
| Jonathan Loaisiga | Undead Rabbits | ADD | to MLB | 12:01 am, 5/20/21 |
| Logan T. Allen | Purple Cobras | ADD | to A | 11:51 am, 5/19/21 |
| Bailey Ober | Purple Cobras | ADD | to MLB | 11:48 am, 5/19/21 |
| Chris Gittens | Bullet Club | ADD | to AAA | 11:47 am, 5/19/21 |