| Player | Team | Action | Details | |
|---|---|---|---|---|
| Thairo Estrada | The Bluth Company | ADD | to AAA | 2:22 pm, 5/25/21 |
| Jonathan Villar | Bullet Club | ADD | to MLB | 1:13 pm, 5/25/21 |
| Jake Burger | Geckos | ADD | to AAA | 11:12 am, 5/25/21 |
| Cornelius Randolph | Undead Rabbits | ADD | to AAA | 12:31 am, 5/25/21 |
| Tyler Duffey | Nixon's Nasty Ninjas | ADD | to MLB | 9:49 pm, 5/24/21 |
| Victor Mesa Jr. | The Red Barons | ADD | to AA | 3:01 pm, 5/24/21 |
| Ryne Nelson | Geckos | ADD | to AA | 11:33 am, 5/24/21 |
| Josh Harrison | Supreme Clientele | ADD | to MLB | 11:14 am, 5/24/21 |
| Glenn Otto | Undead Rabbits | ADD | to AA | 9:57 am, 5/24/21 |
| Asdrubal Cabrera | Purple Cobras | ADD | to MLB | 9:56 am, 5/24/21 |
| Zach Pop | Undead Rabbits | ADD | to MLB | 9:56 am, 5/24/21 |
| Bailey Ober | Purple Cobras | ADD | to AAA | 9:51 am, 5/24/21 |
| Ji-Man Choi | Purple Cobras | ADD | to MLB | 9:25 am, 5/24/21 |
| Brandon Lewis | Geckos | ADD | to AAA | 1:31 am, 5/24/21 |
| Kyle Higashioka | Geckos | ADD | to MLB | 1:20 am, 5/24/21 |
| C.J. Van Eyk | Purple Cobras | ADD | to A | 1:17 am, 5/24/21 |
| Rafael Montero | Cowboys From Hell | ADD | to MLB | 3:49 pm, 5/23/21 |
| Sam Hentges | The Red Barons | ADD | to MLB | 12:38 pm, 5/23/21 |
| Luis Frias | The Bluth Company | ADD | to AAA | 2:03 am, 5/23/21 |
| Garrett Cooper | Bullet Club | ADD | to MLB | 1:08 pm, 5/22/21 |
| Cole Sands | Purple Cobras | ADD | to AA | 1:00 pm, 5/22/21 |
| Patrick Sandoval | The Red Barons | ADD | to MLB | 10:03 am, 5/22/21 |
| Scott Kazmir | The Bluth Company | ADD | to AAA | 8:18 pm, 5/21/21 |
| Miguel Vargas | Chinballs | ADD | to A | 3:26 pm, 5/21/21 |
| Vincent Velasquez | Supreme Clientele | ADD | to MLB | 2:47 pm, 5/21/21 |