| Player | Team | Action | Details | |
|---|---|---|---|---|
| Ryan Helsley | The Bluth Company | ADD | to MLB | 12:43 pm, 4/20/22 |
| Marco Raya | The Bluth Company | ADD | to A | 11:28 am, 4/20/22 |
| Xzavion Curry | Bullet Club | ADD | to AAA | 10:45 am, 4/20/22 |
| Jonah Heim | Monk's Café | ADD | to MLB | 10:08 am, 4/20/22 |
| Will Crowe | The Bluth Company | ADD | to MLB | 7:27 am, 4/20/22 |
| Jalen Beeks | The Bluth Company | ADD | to MLB | 7:26 am, 4/20/22 |
| Joe Ross | The Bluth Company | ADD | to MLB | 7:26 am, 4/20/22 |
| Matt Wisler | The Bluth Company | ADD | to MLB | 9:28 pm, 4/19/22 |
| Sheldon Neuse | Monk's Café | ADD | to MLB | 6:48 pm, 4/19/22 |
| Tyler Wade | Ye Olde Tom Toolshed | ADD | to MLB | 3:43 pm, 4/19/22 |
| Christian Walker | Ye Olde Tom Toolshed | ADD | to MLB | 3:43 pm, 4/19/22 |
| Ken Waldichuk | The Bluth Company | ADD | to AA | 1:18 pm, 4/19/22 |
| Royber Salinas | Monk's Café | ADD | to A | 12:39 pm, 4/19/22 |
| J.P. Feyereisen | Monk's Café | ADD | to MLB | 12:37 pm, 4/19/22 |
| Nick Nastrini | The Bluth Company | ADD | to A | 12:36 pm, 4/19/22 |
| Max Stassi | Supreme Clientele | ADD | to MLB | 10:44 am, 4/19/22 |
| Adael Amador | Chinballs | ADD | to A | 10:25 pm, 4/18/22 |
| Chad Green | Monk's Café | ADD | to MLB | 9:48 pm, 4/18/22 |
| Alex Ramirez | The Bluth Company | ADD | to A | 8:19 pm, 4/18/22 |
| Kyle Stowers | Undead Rabbits | ADD | to MLB | 7:00 pm, 4/18/22 |
| Ceddanne Rafaela | Shaolin Schmeckles | ADD | to A | 6:59 pm, 4/18/22 |
| Emmanuel Rodriguez | Shaolin Schmeckles | ADD | to A | 6:59 pm, 4/18/22 |
| Michael Chavis | Geckos | ADD | to MLB | 10:25 am, 4/18/22 |
| Christian Encarnacion-Strand | The Bluth Company | ADD | to AAA | 10:13 am, 4/18/22 |
| Cristian Pache | Cowboys From Hell | ADD | to MLB | 9:13 pm, 4/17/22 |