| Player | Team | Action | Details | |
|---|---|---|---|---|
| Josh Fleming | The Bluth Company | ADD | to MLB | 6:22 pm, 4/17/22 |
| Brad Keller | Supreme Clientele | ADD | to MLB | 5:47 pm, 4/17/22 |
| Wilmer Flores | Supreme Clientele | ADD | to MLB | 5:47 pm, 4/17/22 |
| Zack Collins | Supreme Clientele | ADD | to MLB | 5:46 pm, 4/17/22 |
| Corbin Martin | Supreme Clientele | ADD | to MLB | 5:46 pm, 4/17/22 |
| Gordon Graceffo | Chinballs | ADD | to A | 2:40 pm, 4/17/22 |
| Thairo Estrada | The Bluth Company | ADD | to MLB | 2:05 pm, 4/17/22 |
| Nick Solak | Geckos | ADD | to MLB | 2:04 pm, 4/17/22 |
| Erick Fedde | Geckos | ADD | to MLB | 2:04 pm, 4/17/22 |
| Clay Holmes | The Bluth Company | ADD | to MLB | 1:24 pm, 4/17/22 |
| Bruce Zimmermann | Undead Rabbits | ADD | to MLB | 11:19 am, 4/17/22 |
| Michael Wacha | Undead Rabbits | ADD | to MLB | 11:18 am, 4/17/22 |
| Taylor Ward | Cowboys From Hell | ADD | to MLB | 9:59 am, 4/17/22 |
| Sean Murphy | The Red Barons | ADD | to MLB | 6:44 am, 4/17/22 |
| Slade Cecconi | Undead Rabbits | ADD | to AA | 1:31 am, 4/17/22 |
| Evan Carter | Undead Rabbits | ADD | to A | 1:30 am, 4/17/22 |
| Josh Staumont | The Red Barons | ADD | to MLB | 10:54 pm, 4/16/22 |
| Josh Rogers | Undead Rabbits | ADD | to MLB | 4:43 pm, 4/16/22 |
| Bryse Wilson | Undead Rabbits | ADD | to MLB | 4:42 pm, 4/16/22 |
| Hansel Robles | Shaolin Schmeckles | ADD | to MLB | 4:15 pm, 4/16/22 |
| Kyle Bradish | The Bluth Company | ADD | to AAA | 3:10 pm, 4/16/22 |
| Masyn Winn | The Bluth Company | ADD | to AA | 2:12 pm, 4/16/22 |
| Felix Valerio | The Bluth Company | ADD | to AAA | 12:34 pm, 4/16/22 |
| Michael McGreevy | Chinballs | ADD | to AA | 12:33 pm, 4/16/22 |
| Miguel Cabrera | Geckos | ADD | to MLB | 10:24 am, 4/16/22 |