| Player | Team | Action | Details | |
|---|---|---|---|---|
| Clayton Beeter | The Bluth Company | ADD | to AAA | 1:05 pm, 5/5/21 |
| Martin Perez | The Bluth Company | ADD | to MLB | 9:29 am, 5/5/21 |
| Lewin Diaz | Purple Cobras | ADD | to AAA | 4:37 am, 5/5/21 |
| Nick Gordon | Purple Cobras | ADD | to AAA | 4:30 am, 5/5/21 |
| Lewis Thorpe | Purple Cobras | ADD | to AAA | 4:16 am, 5/5/21 |
| Roansy Contreras | The Bluth Company | ADD | to AA | 7:56 pm, 5/4/21 |
| Tyrone Taylor | Shaolin Schmeckles | ADD | to AAA | 6:35 pm, 5/4/21 |
| Sam Hentges | Supreme Clientele | ADD | to MLB | 6:01 pm, 5/4/21 |
| Wilmer Flores | Shaolin Schmeckles | ADD | to MLB | 4:29 pm, 5/4/21 |
| Carmen Mlodzinski | The Bluth Company | ADD | to AAA | 3:49 pm, 5/4/21 |
| Ryan Zimmerman | The Bluth Company | ADD | to MLB | 2:13 pm, 5/4/21 |
| Kyle Higashioka | The Bluth Company | ADD | to MLB | 2:02 pm, 5/4/21 |
| Alec Marsh | The Bluth Company | ADD | to AAA | 2:01 pm, 5/4/21 |
| Keegan Akin | The Bluth Company | ADD | to AAA | 1:33 pm, 5/4/21 |
| Brandon Bielak | Purple Cobras | ADD | to AAA | 7:29 am, 5/4/21 |
| Clayton Beeter | The Bluth Company | ADD | to AAA | 1:48 am, 5/4/21 |
| Jonathan Villar | Supreme Clientele | ADD | to MLB | 6:26 pm, 5/3/21 |
| Dan Vogelbach | Supreme Clientele | ADD | to MLB | 6:26 pm, 5/3/21 |
| Trevor May | Purple Cobras | ADD | to MLB | 4:21 pm, 5/3/21 |
| Michael Tauchman | The Bluth Company | ADD | to MLB | 12:06 pm, 5/3/21 |
| Mauricio Dubon | The Red Barons | ADD | to MLB | 11:08 am, 5/3/21 |
| Isan Diaz | Purple Cobras | ADD | to AAA | 8:30 am, 5/3/21 |
| Rafael Montero | Purple Cobras | ADD | to MLB | 8:36 pm, 5/2/21 |
| Joey Cantillo | The Bluth Company | ADD | to AAA | 8:17 pm, 5/2/21 |
| Asdrubal Cabrera | Purple Cobras | ADD | to MLB | 9:33 am, 5/2/21 |