| Player | Team | Action | Details | |
|---|---|---|---|---|
| Samuel Coonrod | Bullet Club | ADD | to MLB | 7:04 am, 5/7/21 |
| Josh Winder | Purple Cobras | ADD | to AAA | 4:16 pm, 5/6/21 |
| Taylor Walls | The Bluth Company | ADD | to AAA | 3:33 pm, 5/6/21 |
| Jose Devers | Scranton Yankees | ADD | to MLB | 3:17 pm, 5/6/21 |
| Adam Duvall | Scranton Yankees | ADD | to MLB | 3:16 pm, 5/6/21 |
| Ryan Zimmerman | Scranton Yankees | ADD | to MLB | 3:16 pm, 5/6/21 |
| Willians Astudillo | Scranton Yankees | ADD | to MLB | 3:16 pm, 5/6/21 |
| Kevin Pillar | Scranton Yankees | ADD | to MLB | 3:14 pm, 5/6/21 |
| Travis Shaw | Scranton Yankees | ADD | to MLB | 3:14 pm, 5/6/21 |
| Kendall Graveman | Scranton Yankees | ADD | to MLB | 3:14 pm, 5/6/21 |
| Jose De Leon | Scranton Yankees | ADD | to MLB | 3:13 pm, 5/6/21 |
| Greg Holland | Scranton Yankees | ADD | to MLB | 3:05 pm, 5/6/21 |
| Rougned Odor | Scranton Yankees | ADD | to MLB | 3:03 pm, 5/6/21 |
| Gabriel Arias | The Bluth Company | ADD | to AA | 12:50 pm, 5/6/21 |
| Starlin Castro | Shaolin Schmeckles | ADD | to MLB | 12:48 pm, 5/6/21 |
| Cole Sands | Purple Cobras | ADD | to AA | 12:19 pm, 5/6/21 |
| Lewis Brinson | Chinballs | ADD | to MLB | 11:07 am, 5/6/21 |
| Nick Pivetta | Chinballs | ADD | to MLB | 10:31 am, 5/6/21 |
| Jordan Luplow | Chinballs | ADD | to MLB | 10:31 am, 5/6/21 |
| Andrew McCutchen | Chinballs | ADD | to MLB | 10:31 am, 5/6/21 |
| Tyrone Taylor | Chinballs | ADD | to MLB | 10:31 am, 5/6/21 |
| Tony Santillan | The Bluth Company | ADD | to AAA | 10:18 am, 5/6/21 |
| Alec Mills | The Bluth Company | ADD | to AAA | 2:43 pm, 5/5/21 |
| Yusmeiro Petit | Undead Rabbits | ADD | to MLB | 2:09 pm, 5/5/21 |
| Nick Pratto | Undead Rabbits | ADD | to AAA | 1:36 pm, 5/5/21 |