| Player | Team | Action | Details | |
|---|---|---|---|---|
| Travis Bergen | Bridge Four | ADD | to MLB | 6:34 pm, 5/8/21 |
| Cory Abbott | Purple Cobras | ADD | to AAA | 1:00 pm, 5/8/21 |
| Zac Lowther | Chinballs | ADD | to AAA | 11:33 am, 5/8/21 |
| Seth Brown | The Bluth Company | ADD | to MLB | 11:02 am, 5/8/21 |
| Alex Dickerson | The Bluth Company | ADD | to MLB | 10:59 am, 5/8/21 |
| Tylor Megill | Geckos | ADD | to AAA | 10:08 am, 5/8/21 |
| Zack Collins | The Red Barons | ADD | to MLB | 9:48 am, 5/8/21 |
| Tyler Beede | The Red Barons | ADD | to MLB | 9:47 am, 5/8/21 |
| Erik Swanson | Cowboys From Hell | ADD | to MLB | 9:40 am, 5/8/21 |
| Keegan Akin | Supreme Clientele | ADD | to AAA | 2:01 am, 5/8/21 |
| Isan Diaz | The Bluth Company | ADD | to AAA | 12:13 am, 5/8/21 |
| Trevor Williams | Supreme Clientele | ADD | to MLB | 9:59 pm, 5/7/21 |
| Owen Miller | Supreme Clientele | ADD | to AA | 9:58 pm, 5/7/21 |
| Mike Zunino | Cowboys From Hell | ADD | to MLB | 4:09 pm, 5/7/21 |
| Edward Olivares | Shaolin Schmeckles | ADD | to AAA | 3:03 pm, 5/7/21 |
| Matt Duffy | Bullet Club | ADD | to MLB | 1:31 pm, 5/7/21 |
| Gabriel Moreno | The Bluth Company | ADD | to A | 1:06 pm, 5/7/21 |
| Miguel Rojas | Purple Cobras | ADD | to MLB | 1:06 pm, 5/7/21 |
| Rowdy Tellez | The Bluth Company | ADD | to AAA | 12:21 pm, 5/7/21 |
| Canaan Smith | Purple Cobras | ADD | to A | 7:49 am, 5/7/21 |
| Samuel Coonrod | Bullet Club | ADD | to MLB | 7:04 am, 5/7/21 |
| Josh Winder | Purple Cobras | ADD | to AAA | 4:16 pm, 5/6/21 |
| Taylor Walls | The Bluth Company | ADD | to AAA | 3:33 pm, 5/6/21 |
| Jose Devers | Scranton Yankees | ADD | to MLB | 3:17 pm, 5/6/21 |
| Adam Duvall | Scranton Yankees | ADD | to MLB | 3:16 pm, 5/6/21 |