| Player | Team | Action | Details | |
|---|---|---|---|---|
| Garrett Cooper | Chinballs | ADD | to MLB | 10:02 am, 4/1/21 |
| Josh Fuentes | Geckos | ADD | to MLB | 2:32 am, 4/1/21 |
| Michael Baumann | The Bluth Company | ADD | to AAA | 1:26 am, 4/1/21 |
| Jhon Torres | The Bluth Company | ADD | to AA | 1:08 am, 4/1/21 |
| William Contreras | The Bluth Company | ADD | to AA | 12:38 am, 4/1/21 |
| Zack Collins | Cowboys From Hell | ADD | to MLB | 7:59 pm, 3/31/21 |
| Myles Straw | Shaolin Schmeckles | ADD | to MLB | 4:34 pm, 3/31/21 |
| Chris Flexen | Supreme Clientele | ADD | to MLB | 4:29 pm, 3/31/21 |
| Jay Bruce | Shaolin Schmeckles | ADD | to MLB | 4:22 pm, 3/31/21 |
| J.B. Bukauskas | Purple Cobras | ADD | to AAA | 3:05 pm, 3/31/21 |
| Ross Stripling | Purple Cobras | ADD | to MLB | 12:56 pm, 3/31/21 |
| Patrick Bailey | The Bluth Company | ADD | to AA | 10:41 am, 3/31/21 |
| Johan Rojas | The Bluth Company | ADD | to A | 10:13 pm, 3/30/21 |
| Colin Barber | The Bluth Company | ADD | to A | 10:07 pm, 3/30/21 |
| Cole Wilcox | The Bluth Company | ADD | to AA | 9:26 pm, 3/30/21 |
| Bobby Bradley | The Bluth Company | ADD | to AAA | 2:02 pm, 3/30/21 |
| Jordan Romero | Chinballs | ADD | to AAA | 12:14 pm, 3/30/21 |
| Kevin Newman | Purple Cobras | ADD | to MLB | 12:13 pm, 3/30/21 |
| Lucas Sims | Purple Cobras | ADD | to MLB | 12:13 pm, 3/30/21 |
| Joshua Mears | Geckos | ADD | to A | 12:13 pm, 3/30/21 |
| Ji-Hwan Bae | The Bluth Company | ADD | to AA | 12:12 pm, 3/30/21 |
| Brenton Doyle | The Bluth Company | ADD | to AAA | 12:11 pm, 3/30/21 |
| Kyle Harrison | The Bluth Company | ADD | to A | 12:11 pm, 3/30/21 |
| Clayton Beeter | The Bluth Company | ADD | to AA | 12:10 pm, 3/30/21 |
| Blake Hunt | The Bluth Company | ADD | to AAA | 12:09 pm, 3/30/21 |