| Player | Team | Action | Details | |
|---|---|---|---|---|
| Kyle Zimmer | Undead Rabbits | ADD | to MLB | 12:26 pm, 5/16/21 |
| Albert Pujols | Undead Rabbits | ADD | to NA | 12:26 pm, 5/16/21 |
| Lorenzo Cain | Chinballs | ADD | to MLB | 9:17 am, 5/16/21 |
| Hansel Robles | Cowboys From Hell | ADD | to MLB | 8:54 am, 5/16/21 |
| Jimmy Nelson | Purple Cobras | ADD | to MLB | 7:05 am, 5/16/21 |
| Austin Adams | The Red Barons | ADD | to MLB | 4:07 pm, 5/15/21 |
| Miguel Rojas | Purple Cobras | ADD | to MLB | 6:49 am, 5/15/21 |
| Matt Beaty | Cowboys From Hell | ADD | to MLB | 8:48 pm, 5/14/21 |
| Mitch Moreland | Cowboys From Hell | ADD | to MLB | 8:47 pm, 5/14/21 |
| Freddy Galvis | Purple Cobras | ADD | to MLB | 7:18 pm, 5/14/21 |
| Erick Fedde | Cowboys From Hell | ADD | to MLB | 7:18 pm, 5/14/21 |
| Will Crowe | Cowboys From Hell | ADD | to MLB | 7:17 pm, 5/14/21 |
| Matt Frisbee | Purple Cobras | ADD | to AAA | 11:44 am, 5/14/21 |
| Josh Winder | The Bluth Company | ADD | to AA | 11:09 am, 5/14/21 |
| Will Craig | The Bluth Company | ADD | to AAA | 10:00 am, 5/14/21 |
| Josh Fuentes | Undead Rabbits | ADD | to MLB | 7:47 am, 5/14/21 |
| Alex Canario | The Bluth Company | ADD | to A | 1:51 am, 5/14/21 |
| Andrew Young | Purple Cobras | ADD | to MLB | 11:38 am, 5/13/21 |
| Masyn Winn | The Bluth Company | ADD | to A | 10:45 am, 5/13/21 |
| Keoni Cavaco | The Bluth Company | ADD | to AA | 10:08 am, 5/13/21 |
| Taylor Widener | Purple Cobras | ADD | to MLB | 7:20 am, 5/13/21 |
| Cody Poteet | The Bluth Company | ADD | to AAA | 1:05 am, 5/13/21 |
| Jake Eder | The Bluth Company | ADD | to AAA | 11:42 pm, 5/12/21 |
| Angel Martinez | Bullet Club | ADD | to A | 11:40 pm, 5/12/21 |
| Andre Jackson | Purple Cobras | ADD | to AAA | 11:39 pm, 5/12/21 |