| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jose Suarez | The Red Barons | ADD | to MLB | 12:22 pm, 8/27/21 |
| Paul Blackburn | The Red Barons | ADD | to MLB | 12:20 pm, 8/27/21 |
| Logan S. Allen | Cowboys From Hell | ADD | to MLB | 5:54 am, 8/27/21 |
| Dallas Keuchel | The Red Barons | ADD | to MLB | 11:21 am, 8/26/21 |
| Adam Engel | Ye Olde Tom Toolshed | ADD | to MLB | 9:48 am, 8/26/21 |
| Kevin Smith | Purple Cobras | ADD | to NA | 7:49 am, 8/26/21 |
| Jamie Barria | Cowboys From Hell | ADD | to MLB | 4:09 am, 8/26/21 |
| Dillon Peters | Shaolin Schmeckles | ADD | to MLB | 3:03 am, 8/26/21 |
| Jordan Romano | Ye Olde Tom Toolshed | ADD | to MLB | 7:48 pm, 8/25/21 |
| Eddys Leonard | The Bluth Company | ADD | to A | 7:29 pm, 8/25/21 |
| Brent Suter | The Red Barons | ADD | to MLB | 4:18 pm, 8/25/21 |
| Yadiel Hernandez | Chinballs | ADD | to MLB | 1:09 pm, 8/25/21 |
| Lane Thomas | The Red Barons | ADD | to MLB | 12:37 pm, 8/25/21 |
| Brian Anderson | Geckos | ADD | to MLB | 11:35 am, 8/25/21 |
| Seth Lugo | The Red Barons | ADD | to MLB | 10:06 am, 8/24/21 |
| Emmanuel Rivera | Cowboys From Hell | ADD | to MLB | 9:11 am, 8/24/21 |
| Garrett Hampson | The Red Barons | ADD | to MLB | 9:00 am, 8/24/21 |
| Andy Ibanez | The Red Barons | ADD | to MLB | 9:00 am, 8/24/21 |
| Corey Knebel | Shaolin Schmeckles | ADD | to MLB | 3:13 am, 8/24/21 |
| Clayton Beeter | The Bluth Company | ADD | to AA | 11:36 pm, 8/23/21 |
| Jake McCarthy | Ye Olde Tom Toolshed | ADD | to AAA | 4:41 pm, 8/23/21 |
| Adam Ottavino | Shaolin Schmeckles | ADD | to MLB | 4:39 pm, 8/23/21 |
| Humberto Mejia | Shaolin Schmeckles | ADD | to MLB | 12:21 pm, 8/23/21 |
| Paul Blackburn | Shaolin Schmeckles | ADD | to MLB | 12:21 pm, 8/23/21 |
| Victor Gonzalez | Shaolin Schmeckles | ADD | to MLB | 3:29 pm, 8/22/21 |