| Player | Team | Action | Details | |
|---|---|---|---|---|
| Joey Lucchesi | The Bluth Company | ADD | to AAA | 5:46 pm, 4/27/21 |
| Stefan Crichton | Shaolin Schmeckles | ADD | to MLB | 3:13 pm, 4/27/21 |
| Brent Suter | Supreme Clientele | ADD | to MLB | 3:07 pm, 4/27/21 |
| Josh Staumont | Supreme Clientele | ADD | to MLB | 3:07 pm, 4/27/21 |
| Jose De Leon | Supreme Clientele | ADD | to MLB | 3:06 pm, 4/27/21 |
| Adam Frazier | Supreme Clientele | ADD | to MLB | 3:06 pm, 4/27/21 |
| Justin Williams | Chinballs | ADD | to MLB | 10:43 am, 4/27/21 |
| Ryne Stanek | Chinballs | ADD | to MLB | 10:42 am, 4/27/21 |
| Corey Dickerson | Purple Cobras | ADD | to MLB | 5:05 am, 4/27/21 |
| Tyrone Taylor | The Red Barons | ADD | to MLB | 6:34 pm, 4/26/21 |
| Ljay Newsome | Supreme Clientele | ADD | to AAA | 5:35 pm, 4/26/21 |
| Mauricio Dubon | Cowboys From Hell | ADD | to MLB | 2:22 pm, 4/26/21 |
| Randal Grichuk | Cowboys From Hell | ADD | to MLB | 2:22 pm, 4/26/21 |
| Erick Fedde | Cowboys From Hell | ADD | to MLB | 2:21 pm, 4/26/21 |
| Scott Barlow | Cowboys From Hell | ADD | to MLB | 2:19 pm, 4/26/21 |
| Gregory Soto | Cowboys From Hell | ADD | to MLB | 2:19 pm, 4/26/21 |
| Sheldon Neuse | Cowboys From Hell | ADD | to AAA | 2:17 pm, 4/26/21 |
| Cesar Hernandez | The Red Barons | ADD | to MLB | 1:32 pm, 4/26/21 |
| Evan Carter | The Bluth Company | ADD | to A | 12:29 pm, 4/26/21 |
| Keegan Akin | Supreme Clientele | ADD | to AA | 12:27 pm, 4/26/21 |
| Tyler Anderson | Supreme Clientele | ADD | to MLB | 10:30 am, 4/26/21 |
| Kolten Wong | Supreme Clientele | ADD | to MLB | 10:27 am, 4/26/21 |
| Will Crowe | Supreme Clientele | ADD | to MLB | 10:27 am, 4/26/21 |
| Josh Harrison | Supreme Clientele | ADD | to MLB | 10:27 am, 4/26/21 |
| Josh Rojas | Supreme Clientele | ADD | to MLB | 10:26 am, 4/26/21 |