| Player | Team | Action | Details | |
|---|---|---|---|---|
| Joey Cantillo | The Bluth Company | ADD | to AAA | 8:17 pm, 5/2/21 |
| Asdrubal Cabrera | Purple Cobras | ADD | to MLB | 9:33 am, 5/2/21 |
| Duane Underwood | Undead Rabbits | ADD | to AAA | 1:22 am, 5/2/21 |
| Dom Nunez | Purple Cobras | ADD | to MLB | 1:01 am, 5/2/21 |
| William Contreras | Supreme Clientele | ADD | to AAA | 11:49 pm, 5/1/21 |
| Drew Strotman | The Bluth Company | ADD | to AAA | 10:53 am, 5/1/21 |
| Willi Castro | The Bluth Company | ADD | to AAA | 9:38 am, 5/1/21 |
| Mitch Moreland | Purple Cobras | ADD | to MLB | 7:14 am, 5/1/21 |
| Chris Owings | Purple Cobras | ADD | to MLB | 7:00 am, 5/1/21 |
| Andrew Knizer | Purple Cobras | ADD | to MLB | 6:59 am, 5/1/21 |
| Edwin Uceta | Geckos | ADD | to AAA | 3:19 pm, 4/30/21 |
| Joey Lucchesi | The Bluth Company | ADD | to AAA | 1:30 pm, 4/30/21 |
| Avisail Garcia | Geckos | ADD | to MLB | 12:51 pm, 4/30/21 |
| Eric Lauer | Supreme Clientele | ADD | to MLB | 12:00 pm, 4/30/21 |
| Genesis Cabrera | Chinballs | ADD | to NA | 11:45 am, 4/30/21 |
| Willians Astudillo | Purple Cobras | ADD | to MLB | 7:43 am, 4/30/21 |
| Josh James | The Red Barons | ADD | to MLB | 6:27 am, 4/30/21 |
| Mike Fiers | Shaolin Schmeckles | ADD | to MLB | 4:41 am, 4/30/21 |
| Genesis Cabrera | Chinballs | ADD | to NA | 6:28 pm, 4/29/21 |
| Yadiel Hernandez | Cowboys From Hell | ADD | to MLB | 7:34 am, 4/29/21 |
| Jonathan Schoop | Cowboys From Hell | ADD | to MLB | 7:34 am, 4/29/21 |
| Brad Miller | The Bluth Company | ADD | to MLB | 7:14 pm, 4/28/21 |
| Sam Haggerty | The Bluth Company | ADD | to AAA | 7:13 pm, 4/28/21 |
| Johan Rojas | The Bluth Company | ADD | to A | 6:47 pm, 4/28/21 |
| Isan Diaz | The Bluth Company | ADD | to AAA | 12:27 pm, 4/28/21 |