| Player | Team | Action | Details | |
|---|---|---|---|---|
| Nick Neidert | Chinballs | ADD | to MLB | 5:13 pm, 4/7/21 |
| Wade Miley | Supreme Clientele | ADD | to MLB | 3:22 pm, 4/7/21 |
| Jake Junis | Bullet Club | ADD | to MLB | 2:08 pm, 4/7/21 |
| Andrew Stevenson | Cowboys From Hell | ADD | to MLB | 11:24 am, 4/7/21 |
| Travis Shaw | Purple Cobras | ADD | to MLB | 10:03 am, 4/7/21 |
| Jonathan Bowlan | Bullet Club | ADD | to AAA | 5:14 pm, 4/6/21 |
| Yasel Antuna | The Red Barons | ADD | to AAA | 10:02 am, 4/6/21 |
| Brandon Bielak | Purple Cobras | ADD | to AAA | 5:05 am, 4/6/21 |
| Evan Longoria | Purple Cobras | ADD | to MLB | 4:57 am, 4/6/21 |
| Drew Strotman | The Bluth Company | ADD | to AA | 12:16 am, 4/6/21 |
| Brandon Williamson | Geckos | ADD | to AA | 10:43 pm, 4/5/21 |
| Omar Narvaez | Purple Cobras | ADD | to MLB | 7:07 pm, 4/5/21 |
| Carter Kieboom | Chinballs | ADD | to AA | 1:41 pm, 4/5/21 |
| Jay Bruce | Geckos | ADD | to MLB | 12:41 pm, 4/5/21 |
| Trevor May | Geckos | ADD | to MLB | 12:40 pm, 4/5/21 |
| Miguel Rojas | Purple Cobras | ADD | to MLB | 10:03 am, 4/5/21 |
| Max Stassi | Purple Cobras | ADD | to MLB | 7:32 am, 4/5/21 |
| Cedric Mullins | Purple Cobras | ADD | to MLB | 4:21 pm, 4/4/21 |
| Zach McKinstry | The Bluth Company | ADD | to AAA | 12:27 pm, 4/4/21 |
| Brett Anderson | Supreme Clientele | ADD | to MLB | 11:43 am, 4/4/21 |
| Max Stassi | Purple Cobras | ADD | to MLB | 3:52 am, 4/4/21 |
| Miguel Cabrera | Purple Cobras | ADD | to MLB | 3:41 am, 4/4/21 |
| Jason Heyward | Purple Cobras | ADD | to MLB | 2:27 am, 4/4/21 |
| Josh Staumont | Geckos | ADD | to MLB | 6:43 pm, 4/3/21 |
| Danny Duffy | Geckos | ADD | to MLB | 6:43 pm, 4/3/21 |