| Player | Team | Action | Details | |
|---|---|---|---|---|
| Oswald Peraza | Cowboys From Hell | ADD | to AA | 12:38 pm, 4/1/21 |
| Alexander Vizcaino | Purple Cobras | ADD | to AAA | 12:38 pm, 4/1/21 |
| Matt Moore | The Red Barons | ADD | to MLB | 12:33 pm, 4/1/21 |
| Tyler Beede | The Red Barons | ADD | to MLB | 12:32 pm, 4/1/21 |
| Jon Berti | Bridge Four | ADD | to MLB | 10:55 am, 4/1/21 |
| Jurickson Profar | Bridge Four | ADD | to MLB | 10:55 am, 4/1/21 |
| Yadier Molina | Ye Olde Tom Toolshed | ADD | to MLB | 10:19 am, 4/1/21 |
| Garrett Cooper | Chinballs | ADD | to MLB | 10:02 am, 4/1/21 |
| Josh Fuentes | Geckos | ADD | to MLB | 2:32 am, 4/1/21 |
| Michael Baumann | The Bluth Company | ADD | to AAA | 1:26 am, 4/1/21 |
| Jhon Torres | The Bluth Company | ADD | to AA | 1:08 am, 4/1/21 |
| William Contreras | The Bluth Company | ADD | to AA | 12:38 am, 4/1/21 |
| Zack Collins | Cowboys From Hell | ADD | to MLB | 7:59 pm, 3/31/21 |
| Myles Straw | Shaolin Schmeckles | ADD | to MLB | 4:34 pm, 3/31/21 |
| Chris Flexen | Supreme Clientele | ADD | to MLB | 4:29 pm, 3/31/21 |
| Jay Bruce | Shaolin Schmeckles | ADD | to MLB | 4:22 pm, 3/31/21 |
| J.B. Bukauskas | Purple Cobras | ADD | to AAA | 3:05 pm, 3/31/21 |
| Ross Stripling | Purple Cobras | ADD | to MLB | 12:56 pm, 3/31/21 |
| Patrick Bailey | The Bluth Company | ADD | to AA | 10:41 am, 3/31/21 |
| Johan Rojas | The Bluth Company | ADD | to A | 10:13 pm, 3/30/21 |
| Colin Barber | The Bluth Company | ADD | to A | 10:07 pm, 3/30/21 |
| Cole Wilcox | The Bluth Company | ADD | to AA | 9:26 pm, 3/30/21 |
| Bobby Bradley | The Bluth Company | ADD | to AAA | 2:02 pm, 3/30/21 |
| Jordan Romero | Chinballs | ADD | to AAA | 12:14 pm, 3/30/21 |
| Kevin Newman | Purple Cobras | ADD | to MLB | 12:13 pm, 3/30/21 |