| Player | Team | Action | Details | |
|---|---|---|---|---|
| Josh Harrison | Supreme Clientele | ADD | to MLB | 11:14 am, 5/24/21 |
| Glenn Otto | Undead Rabbits | ADD | to AA | 9:57 am, 5/24/21 |
| Asdrubal Cabrera | Purple Cobras | ADD | to MLB | 9:56 am, 5/24/21 |
| Zach Pop | Undead Rabbits | ADD | to MLB | 9:56 am, 5/24/21 |
| Bailey Ober | Purple Cobras | ADD | to AAA | 9:51 am, 5/24/21 |
| Ji-Man Choi | Purple Cobras | ADD | to MLB | 9:25 am, 5/24/21 |
| Brandon Lewis | Geckos | ADD | to AAA | 1:31 am, 5/24/21 |
| Kyle Higashioka | Geckos | ADD | to MLB | 1:20 am, 5/24/21 |
| C.J. Van Eyk | Purple Cobras | ADD | to A | 1:17 am, 5/24/21 |
| Rafael Montero | Cowboys From Hell | ADD | to MLB | 3:49 pm, 5/23/21 |
| Sam Hentges | The Red Barons | ADD | to MLB | 12:38 pm, 5/23/21 |
| Luis Frias | The Bluth Company | ADD | to AAA | 2:03 am, 5/23/21 |
| Garrett Cooper | Bullet Club | ADD | to MLB | 1:08 pm, 5/22/21 |
| Cole Sands | Purple Cobras | ADD | to AA | 1:00 pm, 5/22/21 |
| Patrick Sandoval | The Red Barons | ADD | to MLB | 10:03 am, 5/22/21 |
| Scott Kazmir | The Bluth Company | ADD | to AAA | 8:18 pm, 5/21/21 |
| Miguel Vargas | Chinballs | ADD | to A | 3:26 pm, 5/21/21 |
| Vincent Velasquez | Supreme Clientele | ADD | to MLB | 2:47 pm, 5/21/21 |
| Jorge Lopez | Supreme Clientele | ADD | to MLB | 2:46 pm, 5/21/21 |
| Anthony Kay | Supreme Clientele | ADD | to MLB | 2:46 pm, 5/21/21 |
| Randy Dobnak | Supreme Clientele | ADD | to MLB | 2:44 pm, 5/21/21 |
| Patrick Bailey | The Bluth Company | ADD | to AAA | 1:23 pm, 5/21/21 |
| Michael Baumann | The Bluth Company | ADD | to AAA | 1:22 pm, 5/21/21 |
| Brian Rey | Ye Olde Tom Toolshed | ADD | to AAA | 12:49 pm, 5/21/21 |
| Spencer Strider | Shaolin Schmeckles | ADD | to AAA | 12:37 pm, 5/21/21 |