| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jose Rojas | Shaolin Schmeckles | ADD | to MLB | 12:37 pm, 5/21/21 |
| Aaron Ashby | Undead Rabbits | ADD | to AAA | 11:43 am, 5/21/21 |
| Yadiel Hernandez | The Bluth Company | ADD | to AAA | 12:21 am, 5/21/21 |
| Aaron Ashby | Undead Rabbits | ADD | to AAA | 7:10 pm, 5/20/21 |
| Domingo Leyba | Shaolin Schmeckles | ADD | to AAA | 6:52 pm, 5/20/21 |
| Wilson Ramos | Bridge Four | ADD | to MLB | 3:59 pm, 5/20/21 |
| Miguel Rojas | Shaolin Schmeckles | ADD | to MLB | 12:06 pm, 5/20/21 |
| Yonathan Daza | Cowboys From Hell | ADD | to MLB | 10:07 am, 5/20/21 |
| Alex Cobb | Bullet Club | ADD | to MLB | 8:10 am, 5/20/21 |
| Tyler Ivey | Purple Cobras | ADD | to AAA | 7:48 am, 5/20/21 |
| Martin Perez | Undead Rabbits | ADD | to MLB | 12:01 am, 5/20/21 |
| Jonathan Loaisiga | Undead Rabbits | ADD | to MLB | 12:01 am, 5/20/21 |
| Logan T. Allen | Purple Cobras | ADD | to A | 11:51 am, 5/19/21 |
| Bailey Ober | Purple Cobras | ADD | to MLB | 11:48 am, 5/19/21 |
| Chris Gittens | Bullet Club | ADD | to AAA | 11:47 am, 5/19/21 |
| Luis Barrera | Purple Cobras | ADD | to AAA | 11:44 am, 5/19/21 |
| Harold Ramirez | The Bluth Company | ADD | to MLB | 10:15 am, 5/19/21 |
| Tony Santillan | The Bluth Company | ADD | to AAA | 9:40 am, 5/19/21 |
| Andrew Young | Shaolin Schmeckles | ADD | to AAA | 12:20 am, 5/19/21 |
| Yoshitomo Tsutsugo | The Bluth Company | ADD | to MLB | 11:35 pm, 5/18/21 |
| Blayne Enlow | The Bluth Company | ADD | to A | 11:23 pm, 5/18/21 |
| Danny Santana | Shaolin Schmeckles | ADD | to NA | 3:27 pm, 5/18/21 |
| Bruce Zimmermann | Supreme Clientele | ADD | to MLB | 1:23 pm, 5/18/21 |
| Adam Frazier | Supreme Clientele | ADD | to MLB | 1:22 pm, 5/18/21 |
| Ryan Jeffers | Supreme Clientele | ADD | to AAA | 1:22 pm, 5/18/21 |