| Player | Team | Action | Details | |
|---|---|---|---|---|
| Greg Holland | Scranton Yankees | ADD | to MLB | 3:05 pm, 5/6/21 |
| Rougned Odor | Scranton Yankees | ADD | to MLB | 3:03 pm, 5/6/21 |
| Gabriel Arias | The Bluth Company | ADD | to AA | 12:50 pm, 5/6/21 |
| Starlin Castro | Shaolin Schmeckles | ADD | to MLB | 12:48 pm, 5/6/21 |
| Cole Sands | Purple Cobras | ADD | to AA | 12:19 pm, 5/6/21 |
| Lewis Brinson | Chinballs | ADD | to MLB | 11:07 am, 5/6/21 |
| Nick Pivetta | Chinballs | ADD | to MLB | 10:31 am, 5/6/21 |
| Jordan Luplow | Chinballs | ADD | to MLB | 10:31 am, 5/6/21 |
| Andrew McCutchen | Chinballs | ADD | to MLB | 10:31 am, 5/6/21 |
| Tyrone Taylor | Chinballs | ADD | to MLB | 10:31 am, 5/6/21 |
| Tony Santillan | The Bluth Company | ADD | to AAA | 10:18 am, 5/6/21 |
| Alec Mills | The Bluth Company | ADD | to AAA | 2:43 pm, 5/5/21 |
| Yusmeiro Petit | Undead Rabbits | ADD | to MLB | 2:09 pm, 5/5/21 |
| Nick Pratto | Undead Rabbits | ADD | to AAA | 1:36 pm, 5/5/21 |
| Clayton Beeter | The Bluth Company | ADD | to AAA | 1:05 pm, 5/5/21 |
| Martin Perez | The Bluth Company | ADD | to MLB | 9:29 am, 5/5/21 |
| Lewin Diaz | Purple Cobras | ADD | to AAA | 4:37 am, 5/5/21 |
| Nick Gordon | Purple Cobras | ADD | to AAA | 4:30 am, 5/5/21 |
| Lewis Thorpe | Purple Cobras | ADD | to AAA | 4:16 am, 5/5/21 |
| Roansy Contreras | The Bluth Company | ADD | to AA | 7:56 pm, 5/4/21 |
| Tyrone Taylor | Shaolin Schmeckles | ADD | to AAA | 6:35 pm, 5/4/21 |
| Sam Hentges | Supreme Clientele | ADD | to MLB | 6:01 pm, 5/4/21 |
| Wilmer Flores | Shaolin Schmeckles | ADD | to MLB | 4:29 pm, 5/4/21 |
| Carmen Mlodzinski | The Bluth Company | ADD | to AAA | 3:49 pm, 5/4/21 |
| Ryan Zimmerman | The Bluth Company | ADD | to MLB | 2:13 pm, 5/4/21 |