| Player | Team | Action | Details | |
|---|---|---|---|---|
| Erick Fedde | Cowboys From Hell | ADD | to MLB | 2:21 pm, 4/26/21 |
| Scott Barlow | Cowboys From Hell | ADD | to MLB | 2:19 pm, 4/26/21 |
| Gregory Soto | Cowboys From Hell | ADD | to MLB | 2:19 pm, 4/26/21 |
| Sheldon Neuse | Cowboys From Hell | ADD | to AAA | 2:17 pm, 4/26/21 |
| Cesar Hernandez | The Red Barons | ADD | to MLB | 1:32 pm, 4/26/21 |
| Evan Carter | The Bluth Company | ADD | to A | 12:29 pm, 4/26/21 |
| Keegan Akin | Supreme Clientele | ADD | to AA | 12:27 pm, 4/26/21 |
| Tyler Anderson | Supreme Clientele | ADD | to MLB | 10:30 am, 4/26/21 |
| Kolten Wong | Supreme Clientele | ADD | to MLB | 10:27 am, 4/26/21 |
| Will Crowe | Supreme Clientele | ADD | to MLB | 10:27 am, 4/26/21 |
| Josh Harrison | Supreme Clientele | ADD | to MLB | 10:27 am, 4/26/21 |
| Josh Rojas | Supreme Clientele | ADD | to MLB | 10:26 am, 4/26/21 |
| Jeremiah Jackson | Jon Voight's Car | ADD | to AAA | 8:42 am, 4/26/21 |
| Kent Emanuel | Shaolin Schmeckles | ADD | to MLB | 11:36 pm, 4/25/21 |
| Braden Shewmake | Supreme Clientele | ADD | to NA | 9:14 pm, 4/23/21 |
| Martin Perez | Undead Rabbits | ADD | to MLB | 5:34 pm, 4/23/21 |
| J.A. Happ | Supreme Clientele | ADD | to MLB | 1:26 pm, 4/23/21 |
| Kyle Freeland | Supreme Clientele | ADD | to MLB | 1:26 pm, 4/23/21 |
| Patrick Bailey | The Bluth Company | ADD | to A | 11:51 pm, 4/22/21 |
| Kyle Harrison | Bullet Club | ADD | to AA | 10:35 am, 4/22/21 |
| Wilmer Flores | Geckos | ADD | to MLB | 10:17 am, 4/22/21 |
| Seth Brown | The Bluth Company | ADD | to AAA | 8:26 pm, 4/21/21 |
| Pavin Smith | The Bluth Company | ADD | to AAA | 7:12 pm, 4/21/21 |
| Adam Frazier | Geckos | ADD | to MLB | 3:01 pm, 4/21/21 |
| Miguel Rojas | Purple Cobras | ADD | to MLB | 2:19 pm, 4/21/21 |