| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jordan Luplow | Purple Cobras | ADD | to MLB | 2:19 pm, 4/21/21 |
| Drew Rasmussen | Ye Olde Tom Toolshed | ADD | to MLB | 11:29 am, 4/21/21 |
| Ross Stripling | Ye Olde Tom Toolshed | ADD | to MLB | 11:29 am, 4/21/21 |
| Jordan Lyles | The Bluth Company | ADD | to MLB | 10:32 pm, 4/20/21 |
| Aledmys Diaz | Geckos | ADD | to MLB | 1:08 pm, 4/20/21 |
| Yandy Diaz | Geckos | ADD | to MLB | 1:07 pm, 4/20/21 |
| Nick Yorke | Geckos | ADD | to A | 1:02 pm, 4/20/21 |
| Adolis Garcia | Purple Cobras | ADD | to AAA | 12:30 pm, 4/20/21 |
| Harrison Bader | The Red Barons | ADD | to MLB | 9:35 am, 4/20/21 |
| Justin Williams | The Bluth Company | ADD | to AAA | 8:53 pm, 4/19/21 |
| Zack Burdi | The Bluth Company | ADD | to AAA | 12:36 pm, 4/19/21 |
| Patrick Bailey | The Bluth Company | ADD | to AAA | 12:28 pm, 4/19/21 |
| Tyler Matzek | Geckos | ADD | to MLB | 11:42 pm, 4/18/21 |
| J.B. Bukauskas | Purple Cobras | ADD | to AAA | 11:32 am, 4/18/21 |
| Brennan Malone | The Red Barons | ADD | to AA | 6:03 am, 4/18/21 |
| Bobby Bradley | Shaolin Schmeckles | ADD | to AAA | 2:41 pm, 4/17/21 |
| Alex Santos | Geckos | ADD | to A | 10:18 am, 4/17/21 |
| Jalen Beeks | The Red Barons | ADD | to MLB | 9:22 am, 4/17/21 |
| Brett Anderson | Shaolin Schmeckles | ADD | to MLB | 4:01 am, 4/17/21 |
| Ryan Jeffers | The Bluth Company | ADD | to AAA | 10:27 pm, 4/16/21 |
| Drew Strotman | The Bluth Company | ADD | to AAA | 10:02 pm, 4/16/21 |
| Drew Strotman | The Bluth Company | ADD | to AAA | 9:53 pm, 4/16/21 |
| Seth Brown | Shaolin Schmeckles | ADD | to MLB | 6:59 pm, 4/16/21 |
| Jackie Bradley Jr | Bullet Club | ADD | to MLB | 6:40 pm, 4/16/21 |
| Patrick Bailey | The Bluth Company | ADD | to AAA | 5:59 pm, 4/16/21 |