| Player | Team | Action | Details | |
|---|---|---|---|---|
| Mike Brosseau | Cowboys From Hell | ADD | to MLB | 7:37 am, 4/16/21 |
| Corey Dickerson | Cowboys From Hell | ADD | to MLB | 7:36 am, 4/16/21 |
| Lewis Thorpe | The Bluth Company | ADD | to AAA | 1:01 am, 4/16/21 |
| Jed Lowrie | Purple Cobras | ADD | to MLB | 10:30 pm, 4/15/21 |
| Victor Gonzalez | Bullet Club | ADD | to MLB | 8:34 pm, 4/15/21 |
| Willians Astudillo | Shaolin Schmeckles | ADD | to MLB | 4:15 pm, 4/15/21 |
| Corey Ray | Shaolin Schmeckles | ADD | to AAA | 3:37 pm, 4/15/21 |
| Grant Holmes | Shaolin Schmeckles | ADD | to AA | 3:35 pm, 4/15/21 |
| Dillon Dingler | Geckos | ADD | to AA | 3:25 pm, 4/15/21 |
| Patrick Bailey | The Bluth Company | ADD | to AAA | 1:30 am, 4/15/21 |
| Ryan Jeffers | The Bluth Company | ADD | to AAA | 12:43 am, 4/15/21 |
| Adolis Garcia | Purple Cobras | ADD | to AAA | 10:28 pm, 4/14/21 |
| Christian Arroyo | The Red Barons | ADD | to MLB | 9:59 pm, 4/14/21 |
| Aaron Bummer | Shaolin Schmeckles | ADD | to MLB | 7:30 pm, 4/14/21 |
| Abraham Toro | Geckos | ADD | to AAA | 4:30 pm, 4/14/21 |
| Lucas Sims | Purple Cobras | ADD | to MLB | 3:28 pm, 4/14/21 |
| Rowdy Tellez | Purple Cobras | ADD | to MLB | 3:28 pm, 4/14/21 |
| Alex Wood | The Red Barons | ADD | to MLB | 1:08 pm, 4/14/21 |
| Rafael Dolis | Cowboys From Hell | ADD | to MLB | 12:44 pm, 4/14/21 |
| Patrick Bailey | The Bluth Company | ADD | to AAA | 1:49 am, 4/14/21 |
| Brett Phillips | Cowboys From Hell | ADD | to MLB | 5:36 pm, 4/13/21 |
| Chris Owings | Cowboys From Hell | ADD | to MLB | 4:01 pm, 4/13/21 |
| Yan Gomes | Cowboys From Hell | ADD | to MLB | 4:01 pm, 4/13/21 |
| Wilson Ramos | Cowboys From Hell | ADD | to MLB | 4:01 pm, 4/13/21 |
| Trevor Cahill | Kimble's Kids | ADD | to MLB | 1:22 pm, 4/13/21 |