| Player | Team | Action | Details | |
|---|---|---|---|---|
| Michael Harris | Supreme Clientele | ADD | to MLB | 5:49 pm, 3/22/21 |
| Kevin Pillar | Undead Rabbits | ADD | to MLB | 3:15 pm, 3/22/21 |
| Starlin Castro | Undead Rabbits | ADD | to MLB | 3:14 pm, 3/22/21 |
| Akil Baddoo | Purple Cobras | ADD | to AA | 8:56 pm, 3/21/21 |
| Josh Rojas | Purple Cobras | ADD | to MLB | 6:57 am, 3/19/21 |
| Carter Kieboom | Purple Cobras | ADD | to AAA | 6:42 am, 3/19/21 |
| Reyes Moronta | Chinballs | ADD | to MLB | 5:55 pm, 3/18/21 |
| Tanner Scott | Chinballs | ADD | to MLB | 11:45 am, 3/18/21 |
| Avisail Garcia | The Red Barons | ADD | to MLB | 4:01 pm, 3/16/21 |
| Lenny Torres | Chinballs | ADD | to A | 10:46 am, 3/16/21 |
| Yasel Antuna | Purple Cobras | ADD | to A | 9:40 am, 3/16/21 |
| Ryan Pepiot | Chinballs | ADD | to AAA | 12:52 am, 3/16/21 |
| Jonatan Clase | Chinballs | ADD | to A | 12:51 am, 3/16/21 |
| Luis Oviedo | Chinballs | ADD | to A | 12:43 am, 3/16/21 |
| Michael Grove | Chinballs | ADD | to AA | 12:41 am, 3/16/21 |
| Hunter Harvey | Chinballs | ADD | to AAA | 12:38 am, 3/16/21 |
| James Kaprielian | Chinballs | ADD | to AAA | 12:35 am, 3/16/21 |
| Brennan Malone | Chinballs | ADD | to A | 12:32 am, 3/16/21 |
| Adam Ottavino | Undead Rabbits | ADD | to MLB | 12:06 am, 3/16/21 |
| Gregory Polanco | Shaolin Schmeckles | ADD | to MLB | 12:06 am, 3/16/21 |
| Chad Kuhl | Cowboys From Hell | ADD | to MLB | 12:05 am, 3/16/21 |
| Wilmer Flores | Shaolin Schmeckles | ADD | to MLB | 12:04 am, 3/16/21 |
| Yoendrys Gomez | The Bluth Company | ADD | to AA | 12:03 am, 3/16/21 |
| Tyler Duffey | Nixon's Nasty Ninjas | ADD | to MLB | 12:03 am, 3/16/21 |
| Austin Gomber | The Red Barons | ADD | to MLB | 12:01 am, 3/16/21 |