| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jake McGee | Monk's Café | DROP | to FA | 10:44 pm, 5/7/22 |
| Peyton Battenfield | Monk's Café | DROP | to FA | 10:44 pm, 5/7/22 |
| Andre Jackson | Monk's Café | DROP | to FA | 10:42 pm, 5/7/22 |
| Yosver Zulueta | The Bluth Company | DROP | to FA | 1:34 am, 5/7/22 |
| William Contreras | Scranton Yankees | DROP | to FA | 8:31 pm, 5/6/22 |
| Trevor Stephan | The Bluth Company | DROP | to FA | 3:23 pm, 5/6/22 |
| Marco Raya | The Bluth Company | DROP | to FA | 2:19 pm, 5/6/22 |
| Jorge Mateo | Monk's Café | DROP | to FA | 5:53 am, 5/6/22 |
| Taylor Walls | The Bluth Company | DROP | to FA | 5:24 pm, 5/5/22 |
| Zack Collins | Supreme Clientele | DROP | to FA | 3:23 pm, 5/5/22 |
| Garrett Cooper | Supreme Clientele | DROP | to FA | 3:23 pm, 5/5/22 |
| Yosver Zulueta | The Bluth Company | DROP | to FA | 11:54 pm, 5/4/22 |
| Jake Burger | Geckos | DROP | to FA | 7:10 pm, 5/4/22 |
| Michael Massey | Geckos | DROP | to FA | 1:33 pm, 5/4/22 |
| Jose Butto | Geckos | DROP | to FA | 1:05 pm, 5/4/22 |
| Chad Pinder | Chinballs | DROP | to FA | 11:21 am, 5/4/22 |
| Dan Vogelbach | Chinballs | DROP | to FA | 11:11 am, 5/4/22 |
| Joey Wendle | Chinballs | DROP | to FA | 11:11 am, 5/4/22 |
| Jose Trevino | Monk's Café | DROP | to FA | 8:36 am, 5/4/22 |
| Enrique Hernandez | Undead Rabbits | DROP | to FA | 7:02 am, 5/4/22 |
| Hansel Robles | Shaolin Schmeckles | DROP | to FA | 12:16 am, 5/4/22 |
| Chris Stratton | Shaolin Schmeckles | DROP | to FA | 12:15 am, 5/4/22 |
| Brock Burke | The Bluth Company | DROP | to FA | 9:02 pm, 5/3/22 |
| Andy Ibanez | The Red Barons | DROP | to FA | 5:26 pm, 5/3/22 |
| Cristian Pache | Cowboys From Hell | DROP | to FA | 5:13 pm, 5/3/22 |