| Player | Team | Action | Details | |
|---|---|---|---|---|
| Miguel Sano | The Red Barons | DROP | to FA | 6:25 pm, 7/30/22 |
| Asa Lacy | Supreme Clientele | DROP | to FA | 4:41 pm, 7/30/22 |
| Josh Winder | Supreme Clientele | DROP | to FA | 3:32 pm, 7/30/22 |
| Jose Urena | Scranton Yankees | DROP | to FA | 2:49 pm, 7/30/22 |
| Dan Jansen | Scranton Yankees | DROP | to FA | 2:45 pm, 7/30/22 |
| Luis Rengifo | The Red Barons | DROP | to FA | 2:14 pm, 7/30/22 |
| Jose Suarez | Geckos | DROP | to FA | 10:48 am, 7/30/22 |
| Jurickson Profar | Shaolin Schmeckles | DROP | to FA | 8:24 am, 7/30/22 |
| Ji-Man Choi | Chinballs | DROP | to FA | 5:40 am, 7/30/22 |
| Carlos Santana | Bullet Club | DROP | to FA | 12:41 am, 7/30/22 |
| Hunter Strickland | The Red Barons | DROP | to FA | 10:33 pm, 7/29/22 |
| Matt Krook | Geckos | DROP | to FA | 1:23 pm, 7/29/22 |
| Frank Schwindel | Geckos | DROP | to FA | 1:19 pm, 7/29/22 |
| Jackson (Clint) Frazier | Scranton Yankees | DROP | to FA | 1:19 pm, 7/29/22 |
| Michael McGreevy | Chinballs | DROP | to FA | 9:27 am, 7/28/22 |
| Pavin Smith | Bridge Four | DROP | to FA | 9:23 am, 7/28/22 |
| Brad Miller | Bridge Four | DROP | to FA | 9:23 am, 7/28/22 |
| Ryan Weathers | Bridge Four | DROP | to FA | 9:17 am, 7/28/22 |
| Bryan Ramos | Chinballs | DROP | to FA | 3:16 am, 7/28/22 |
| Hunter Dozier | Chinballs | DROP | to FA | 3:15 am, 7/28/22 |
| Jeremiah Jackson | The Red Barons | DROP | to FA | 11:03 pm, 7/27/22 |
| Nick Nastrini | The Bluth Company | DROP | to FA | 10:13 pm, 7/27/22 |
| Endy Rodriguez | The Bluth Company | DROP | to FA | 1:10 pm, 7/27/22 |
| Jose Salas | The Bluth Company | DROP | to FA | 1:16 am, 7/27/22 |
| Colin Poche | Undead Rabbits | DROP | to FA | 12:21 pm, 7/26/22 |