| Player | Team | Action | Details | |
|---|---|---|---|---|
| Jalen Beeks | The Red Barons | DROP | to FA | 3:48 pm, 5/3/22 |
| Nicky Lopez | Bullet Club | DROP | to FA | 2:20 pm, 5/3/22 |
| Ross Stripling | The Bluth Company | DROP | to FA | 6:45 am, 5/3/22 |
| Freddy Tarnok | The Bluth Company | DROP | to FA | 6:43 am, 5/3/22 |
| Martin Perez | The Bluth Company | DROP | to FA | 11:44 pm, 5/2/22 |
| Gio Urshela | The Bluth Company | DROP | to FA | 11:00 pm, 5/2/22 |
| Carlos Martinez | Scranton Yankees | DROP | to FA | 10:36 pm, 5/2/22 |
| Kyle Higashioka | Monk's Café | DROP | to FA | 5:04 pm, 5/2/22 |
| Johan Camargo | Supreme Clientele | DROP | to FA | 3:35 pm, 5/2/22 |
| Jonah Heim | Monk's Café | DROP | to FA | 3:34 pm, 5/2/22 |
| Rich Hill | Undead Rabbits | DROP | to FA | 11:17 am, 5/2/22 |
| Odubel Herrera | Geckos | DROP | to FA | 10:04 am, 5/2/22 |
| Brian Anderson | Geckos | DROP | to FA | 10:04 am, 5/2/22 |
| Drew Steckenrider | Ye Olde Tom Toolshed | DROP | to FA | 9:24 am, 5/2/22 |
| Rafael Ortega | Ye Olde Tom Toolshed | DROP | to FA | 9:23 am, 5/2/22 |
| Tyler Wade | Ye Olde Tom Toolshed | DROP | to FA | 9:23 am, 5/2/22 |
| Josh Staumont | The Red Barons | DROP | to FA | 8:46 am, 5/2/22 |
| Erik Swanson | The Bluth Company | DROP | to FA | 6:21 pm, 5/1/22 |
| Miguel Andujar | Cowboys From Hell | DROP | to FA | 9:30 am, 5/1/22 |
| Richie Palacios | Cowboys From Hell | DROP | to FA | 9:30 am, 5/1/22 |
| Maikel Franco | The Red Barons | DROP | to FA | 6:33 am, 5/1/22 |
| Jordan Westburg | The Bluth Company | DROP | to FA | 9:55 pm, 4/30/22 |
| Nick Nastrini | The Bluth Company | DROP | to FA | 9:47 pm, 4/30/22 |
| Steven Wilson | The Bluth Company | DROP | to FA | 9:19 pm, 4/30/22 |
| Huascar Ynoa | Supreme Clientele | DROP | to FA | 7:40 pm, 4/30/22 |