| Player | Team | Action | Details | |
|---|---|---|---|---|
| Adam Ottavino | Geckos | DROP | to FA | 1:50 pm, 4/12/22 |
| Gabriel Arias | The Bluth Company | DROP | to FA | 1:49 pm, 4/12/22 |
| Christian Encarnacion-Strand | The Bluth Company | DROP | to FA | 1:47 pm, 4/12/22 |
| Andrew McCutchen | The Red Barons | DROP | to FA | 10:43 am, 4/12/22 |
| Dillon Tate | Monk's Café | DROP | to FA | 7:06 pm, 4/11/22 |
| Willie Calhoun | Monk's Café | DROP | to FA | 6:10 pm, 4/11/22 |
| Aaron Sabato | The Red Barons | DROP | to FA | 3:42 pm, 4/11/22 |
| Thairo Estrada | The Bluth Company | DROP | to FA | 9:21 am, 4/11/22 |
| Robinson Cano | Cowboys From Hell | DROP | to FA | 10:52 pm, 4/10/22 |
| Aledmys Diaz | Shaolin Schmeckles | DROP | to FA | 10:05 pm, 4/10/22 |
| J.D. Davis | Shaolin Schmeckles | DROP | to FA | 10:04 pm, 4/10/22 |
| Mitchell White | The Bluth Company | DROP | to FA | 8:17 pm, 4/10/22 |
| Jose Tena | Geckos | DROP | to FA | 8:06 pm, 4/10/22 |
| Yandy Diaz | Geckos | DROP | to FA | 2:02 pm, 4/10/22 |
| Cooper Hummel | The Bluth Company | DROP | to FA | 2:02 pm, 4/10/22 |
| Jorge Alcala | Cowboys From Hell | DROP | to FA | 6:51 am, 4/9/22 |
| Josh Harrison | Monk's Café | DROP | to FA | 6:42 am, 4/9/22 |
| Matthew Frazier | The Bluth Company | DROP | to FA | 8:04 pm, 4/8/22 |
| Dillon Dingler | Geckos | DROP | to FA | 12:54 pm, 4/8/22 |
| Aristides Aquino | Bullet Club | DROP | to FA | 12:50 pm, 4/8/22 |
| Christian Walker | Cowboys From Hell | DROP | to FA | 12:20 pm, 4/8/22 |
| Michael Wacha | Supreme Clientele | DROP | to FA | 11:53 am, 4/8/22 |
| Collin McHugh | The Bluth Company | DROP | to FA | 9:39 am, 4/8/22 |
| Isaiah Greene | Scranton Yankees | DROP | to FA | 6:45 am, 4/8/22 |
| Bryce Jarvis | Scranton Yankees | DROP | to FA | 6:45 am, 4/8/22 |