| Player | Team | Action | Details | |
|---|---|---|---|---|
| Andrew Chafin | The Red Barons | DROP | to FA | 8:57 am, 3/16/22 |
| Chris Stratton | The Red Barons | DROP | to FA | 8:57 am, 3/16/22 |
| J.P. Crawford | The Red Barons | DROP | to FA | 8:57 am, 3/16/22 |
| Michael Fulmer | Undead Rabbits | DROP | to FA | 11:10 pm, 3/15/22 |
| Matt Barnes | Undead Rabbits | DROP | to FA | 5:25 pm, 3/14/22 |
| Drew Pomeranz | Scranton Yankees | DROP | to FA | 5:21 pm, 3/14/22 |
| Martin Perez | Scranton Yankees | DROP | to FA | 5:20 pm, 3/14/22 |
| Colin Moran | Ye Olde Tom Toolshed | DROP | to FA | 10:39 am, 3/14/22 |
| Trevor Stephan | Ye Olde Tom Toolshed | DROP | to FA | 10:38 am, 3/14/22 |
| Yohel Pozo | Ye Olde Tom Toolshed | DROP | to FA | 10:37 am, 3/14/22 |
| Adam Engel | Ye Olde Tom Toolshed | DROP | to FA | 10:32 am, 3/14/22 |
| Bryce Ball | Ye Olde Tom Toolshed | DROP | to FA | 10:32 am, 3/14/22 |
| Evan White | Ye Olde Tom Toolshed | DROP | to FA | 10:32 am, 3/14/22 |
| Matt Tabor | Ye Olde Tom Toolshed | DROP | to FA | 10:28 am, 3/14/22 |
| Sheldon Neuse | Ye Olde Tom Toolshed | DROP | to FA | 10:27 am, 3/14/22 |
| James Paxton | Chinballs | DROP | to FA | 6:13 am, 3/11/22 |
| Jonathan Loaisiga | Chinballs | DROP | to FA | 6:03 am, 3/11/22 |
| Carter Kieboom | Chinballs | DROP | to FA | 5:20 am, 3/11/22 |
| Logan T. Allen | Kimble's Kids | DROP | to FA | 3:59 pm, 2/20/22 |
| Edward Cabrera | Kimble's Kids | DROP | to FA | 3:59 pm, 2/20/22 |
| Spencer Torkelson | Kimble's Kids | DROP | to FA | 3:59 pm, 2/20/22 |
| Taj Bradley | Kimble's Kids | DROP | to FA | 3:59 pm, 2/20/22 |
| Kyle Muller | Kimble's Kids | DROP | to FA | 3:59 pm, 2/20/22 |
| Braxton Garrett | Kimble's Kids | DROP | to FA | 3:59 pm, 2/20/22 |
| Jackson Kowar | Kimble's Kids | DROP | to FA | 3:59 pm, 2/20/22 |