| Player | Team | Action | Details | |
|---|---|---|---|---|
| Ryan Vilade | Ye Olde Tom Toolshed | DROP | to FA | 12:05 pm, 3/22/22 |
| Jake McCarthy | Ye Olde Tom Toolshed | DROP | to FA | 12:04 pm, 3/22/22 |
| Didi Gregorious | Bullet Club | DROP | to FA | 12:53 am, 3/22/22 |
| Misael Urbina | Bullet Club | DROP | to FA | 12:50 am, 3/22/22 |
| Bubba Thompson | Bullet Club | DROP | to FA | 12:50 am, 3/22/22 |
| Dallas Keuchel | Bullet Club | DROP | to FA | 12:49 am, 3/22/22 |
| Taylor Hearn | Bullet Club | DROP | to FA | 12:49 am, 3/22/22 |
| Jose Siri | Bullet Club | DROP | to FA | 12:49 am, 3/22/22 |
| Rodolfo Castro | Bullet Club | DROP | to FA | 12:45 am, 3/22/22 |
| Chris Archer | Undead Rabbits | DROP | to FA | 11:31 am, 3/21/22 |
| Estevan Florial | Nixon's Nasty Ninjas | DROP | to FA | 9:25 am, 3/21/22 |
| Joshua Mears | The Bluth Company | DROP | to FA | 9:05 am, 3/21/22 |
| Freddy Tarnok | The Bluth Company | DROP | to FA | 9:05 am, 3/21/22 |
| Sam Long | The Bluth Company | DROP | to FA | 9:04 am, 3/21/22 |
| Ryan Yarbrough | The Bluth Company | DROP | to FA | 9:04 am, 3/21/22 |
| Tommy La Stella | The Bluth Company | DROP | to FA | 9:04 am, 3/21/22 |
| Darin Ruf | The Bluth Company | DROP | to FA | 9:04 am, 3/21/22 |
| Buster Posey | The Bluth Company | DROP | to FA | 9:04 am, 3/21/22 |
| Zach Logue | Nixon's Nasty Ninjas | DROP | to FA | 9:33 pm, 3/20/22 |
| Bryan Mata | Nixon's Nasty Ninjas | DROP | to FA | 9:26 pm, 3/20/22 |
| Isaac Paredes | Nixon's Nasty Ninjas | DROP | to FA | 9:26 pm, 3/20/22 |
| Michael Toglia | Supreme Clientele | DROP | to FA | 9:21 pm, 3/20/22 |
| Nolan Jones | Supreme Clientele | DROP | to FA | 9:21 pm, 3/20/22 |
| Craig Stammen | Nixon's Nasty Ninjas | DROP | to FA | 9:13 pm, 3/20/22 |
| Domingo German | Chinballs | DROP | to FA | 10:45 pm, 3/17/22 |