| Player | Team | Action | Details | |
|---|---|---|---|---|
| Brad Hand | Ye Olde Tom Toolshed | DROP | to FA | 2:22 pm, 9/2/21 |
| Richard Rodriguez | Supreme Clientele | DROP | to FA | 11:57 am, 9/2/21 |
| Pedro Severino | The Red Barons | DROP | to FA | 9:37 am, 9/2/21 |
| Jose Marmolejos | The Red Barons | DROP | to FA | 9:36 am, 9/2/21 |
| Emmanuel Rivera | Cowboys From Hell | DROP | to FA | 8:50 am, 9/2/21 |
| Lars Nootbaar | Cowboys From Hell | DROP | to FA | 8:50 am, 9/2/21 |
| Jeremy Pena | The Bluth Company | DROP | to FA | 11:47 pm, 9/1/21 |
| Steven Brault | Bullet Club | DROP | to FA | 2:28 pm, 9/1/21 |
| Daz Cameron | Bullet Club | DROP | to FA | 2:27 pm, 9/1/21 |
| Jorge Alfaro | The Red Barons | DROP | to FA | 12:04 pm, 9/1/21 |
| Luis Rodriguez | The Red Barons | DROP | to FA | 12:05 pm, 8/31/21 |
| Mitchell White | The Bluth Company | DROP | to FA | 11:33 am, 8/31/21 |
| Dylan Moore | Bullet Club | DROP | to FA | 7:53 pm, 8/30/21 |
| Adrian Houser | The Red Barons | DROP | to FA | 2:24 pm, 8/30/21 |
| Bradley Zimmer | Purple Cobras | DROP | to FA | 9:07 am, 8/30/21 |
| Wandy Peralta | The Red Barons | DROP | to FA | 10:09 pm, 8/29/21 |
| Dallas Keuchel | The Red Barons | DROP | to FA | 10:09 pm, 8/29/21 |
| Paul Blackburn | The Red Barons | DROP | to FA | 10:08 pm, 8/29/21 |
| Andy Ibanez | The Red Barons | DROP | to FA | 10:08 pm, 8/29/21 |
| Jose Suarez | The Red Barons | DROP | to FA | 10:08 pm, 8/29/21 |
| Yasel Antuna | The Red Barons | DROP | to FA | 7:22 pm, 8/29/21 |
| Taylor Motter | Shaolin Schmeckles | DROP | to FA | 3:52 pm, 8/29/21 |
| Kevin Smith | Purple Cobras | DROP | to FA | 1:00 am, 8/29/21 |
| Gio Urshela | Purple Cobras | DROP | to FA | 12:51 am, 8/29/21 |
| Zack Littell | Shaolin Schmeckles | DROP | to FA | 8:24 pm, 8/28/21 |