| Player | Team | Action | Details | |
|---|---|---|---|---|
| Humberto Castellanos | The Bluth Company | DROP | to FA | 10:06 pm, 9/14/21 |
| Zac Lowther | The Red Barons | DROP | to FA | 12:09 pm, 9/13/21 |
| Yadier Molina | Purple Cobras | DROP | to FA | 12:58 am, 9/13/21 |
| Corey Kluber | Purple Cobras | DROP | to FA | 11:00 am, 9/12/21 |
| Eli Morgan | Purple Cobras | DROP | to FA | 5:53 pm, 9/11/21 |
| Gabriel Arias | Purple Cobras | DROP | to FA | 8:01 pm, 9/10/21 |
| Alec Marsh | Purple Cobras | DROP | to FA | 8:00 pm, 9/10/21 |
| Jorge Alfaro | Bullet Club | DROP | to FA | 12:01 am, 9/10/21 |
| Yadiel Hernandez | Chinballs | DROP | to FA | 1:19 pm, 9/9/21 |
| Omar Narvaez | Purple Cobras | DROP | to FA | 9:35 am, 9/9/21 |
| Thairo Estrada | The Bluth Company | DROP | to FA | 11:41 pm, 9/8/21 |
| Alec Burleson | The Bluth Company | DROP | to FA | 11:40 pm, 9/8/21 |
| Lorenzo Cain | Purple Cobras | DROP | to FA | 12:26 am, 9/8/21 |
| Thomas Hatch | Bullet Club | DROP | to FA | 11:20 pm, 9/7/21 |
| Taylor Motter | Shaolin Schmeckles | DROP | to FA | 5:22 pm, 9/6/21 |
| Andrew Heaney | Purple Cobras | DROP | to FA | 12:07 pm, 9/6/21 |
| A.J. Puk | Supreme Clientele | DROP | to FA | 10:42 am, 9/6/21 |
| Chris Stratton | The Red Barons | DROP | to FA | 9:58 am, 9/6/21 |
| Janson Junk | The Bluth Company | DROP | to FA | 8:13 pm, 9/5/21 |
| Jose Suarez | The Bluth Company | DROP | to FA | 10:22 am, 9/5/21 |
| Rowan Wick | Purple Cobras | DROP | to FA | 5:35 am, 9/5/21 |
| Humberto Mejia | Shaolin Schmeckles | DROP | to FA | 11:11 am, 9/4/21 |
| Joey Wendle | Purple Cobras | DROP | to FA | 8:56 am, 9/4/21 |
| J.A. Happ | Bullet Club | DROP | to FA | 7:01 am, 9/3/21 |
| Austin Hays | Purple Cobras | DROP | to FA | 3:52 am, 9/3/21 |