| Player | Team | Action | Details | |
|---|---|---|---|---|
| Tommy La Stella | The Bluth Company | DROP | to FA | 6:26 pm, 8/11/21 |
| Pete Fairbanks | Geckos | DROP | to FA | 5:57 pm, 8/11/21 |
| Miguel Rojas | Geckos | DROP | to FA | 5:56 pm, 8/11/21 |
| Mike Foltynewicz | Scranton Yankees | DROP | to FA | 11:08 pm, 8/10/21 |
| Archie Bradley | Scranton Yankees | DROP | to FA | 11:06 pm, 8/10/21 |
| Aaron Sanchez | Bullet Club | DROP | to FA | 10:35 pm, 8/10/21 |
| Orlando Arcia | Scranton Yankees | DROP | to FA | 8:53 pm, 8/10/21 |
| Matt Moore | Scranton Yankees | DROP | to FA | 8:48 pm, 8/10/21 |
| Josh Harrison | Scranton Yankees | DROP | to FA | 8:48 pm, 8/10/21 |
| Chad Kuhl | The Red Barons | DROP | to FA | 7:00 pm, 8/10/21 |
| Zack Britton | The Red Barons | DROP | to FA | 10:07 am, 8/10/21 |
| Cole Ragans | Purple Cobras | DROP | to FA | 7:32 am, 8/10/21 |
| Zach McCambley | Purple Cobras | DROP | to FA | 6:56 am, 8/10/21 |
| Carlos Santana | Purple Cobras | DROP | to FA | 6:27 am, 8/10/21 |
| Greg Holland | Shaolin Schmeckles | DROP | to FA | 5:40 am, 8/9/21 |
| Heath Hembree | Shaolin Schmeckles | DROP | to FA | 5:12 am, 8/9/21 |
| Dillon Tate | Cowboys From Hell | DROP | to FA | 2:45 pm, 8/8/21 |
| Aledmys Diaz | The Bluth Company | DROP | to FA | 1:12 pm, 8/8/21 |
| Justin Upton | The Red Barons | DROP | to FA | 8:24 am, 8/8/21 |
| Josh James | The Red Barons | DROP | to FA | 8:21 am, 8/8/21 |
| Wilmer Flores | Purple Cobras | DROP | to FA | 5:08 am, 8/8/21 |
| Brent Rooker | Nixon's Nasty Ninjas | DROP | to FA | 9:23 am, 8/7/21 |
| Alex Dickerson | Purple Cobras | DROP | to FA | 3:17 am, 8/7/21 |
| Carlos Santana | The Bluth Company | DROP | to FA | 1:56 pm, 8/6/21 |
| Blaze Jordan | The Red Barons | DROP | to FA | 11:58 pm, 8/5/21 |