| Player | Team | Action | Details | |
|---|---|---|---|---|
| Tyrone Taylor | Purple Cobras | DROP | to FA | 11:15 am, 8/5/21 |
| Seth Lugo | Chinballs | DROP | to FA | 4:53 am, 8/5/21 |
| Wily Peralta | Undead Rabbits | DROP | to FA | 5:28 pm, 8/4/21 |
| Adam Haseley | Jon Voight's Car | DROP | to FA | 4:30 pm, 8/4/21 |
| Brandon Pfaadt | Geckos | DROP | to FA | 10:54 am, 8/4/21 |
| Drew Ellis | Purple Cobras | DROP | to FA | 5:25 am, 8/4/21 |
| Matt Harvey | Kimble's Kids | DROP | to FA | 4:25 pm, 8/3/21 |
| Masyn Winn | The Bluth Company | DROP | to FA | 4:25 pm, 8/3/21 |
| Adam Ottavino | Scranton Yankees | DROP | to FA | 4:23 pm, 8/3/21 |
| Robert Dominguez | The Red Barons | DROP | to FA | 1:19 pm, 8/3/21 |
| Austin Hays | Chinballs | DROP | to FA | 4:05 pm, 8/2/21 |
| Emilio Pagán | Ye Olde Tom Toolshed | DROP | to FA | 11:46 am, 8/2/21 |
| Alec Mills | Ye Olde Tom Toolshed | DROP | to FA | 11:46 am, 8/2/21 |
| Ben Gamel | Ye Olde Tom Toolshed | DROP | to FA | 11:46 am, 8/2/21 |
| Yadier Molina | Ye Olde Tom Toolshed | DROP | to FA | 11:45 am, 8/2/21 |
| Jared Oliva | Chinballs | DROP | to FA | 10:29 am, 8/2/21 |
| Hansel Robles | Cowboys From Hell | DROP | to FA | 9:43 am, 8/2/21 |
| Taylor Widener | Purple Cobras | DROP | to FA | 8:49 am, 8/2/21 |
| Jhonkensy Noel | The Bluth Company | DROP | to FA | 1:50 am, 8/2/21 |
| Ken Waldichuk | The Bluth Company | DROP | to FA | 12:18 am, 8/2/21 |
| Aaron Ashby | Undead Rabbits | DROP | to FA | 11:21 pm, 8/1/21 |
| Rex Brothers | The Red Barons | DROP | to FA | 9:40 pm, 8/1/21 |
| Jake Woodford | Purple Cobras | DROP | to FA | 8:12 pm, 8/1/21 |
| Reynaldo Lopez | The Bluth Company | DROP | to FA | 3:09 am, 8/1/21 |
| Mickey Moniak | Shaolin Schmeckles | DROP | to FA | 6:59 pm, 7/31/21 |